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Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial
Background: This study was carried out to evaluate enteral feeding advancement and tolerance in preterm infants receiving one of two marketed formulas: intact protein preterm formula (IPF) or extensively hydrolyzed formula (EHF) for the first 14 feeding days. Methods: Primary outcome was days to ful...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720977/ https://www.ncbi.nlm.nih.gov/pubmed/31416171 http://dx.doi.org/10.3390/ijerph16162911 |
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author | Baldassarre, Maria Elisabetta Di Mauro, Antonio Fanelli, Margherita Capozza, Manuela Wampler, Jennifer L. Cooper, Timothy Laforgia, Nicola |
author_facet | Baldassarre, Maria Elisabetta Di Mauro, Antonio Fanelli, Margherita Capozza, Manuela Wampler, Jennifer L. Cooper, Timothy Laforgia, Nicola |
author_sort | Baldassarre, Maria Elisabetta |
collection | PubMed |
description | Background: This study was carried out to evaluate enteral feeding advancement and tolerance in preterm infants receiving one of two marketed formulas: intact protein preterm formula (IPF) or extensively hydrolyzed formula (EHF) for the first 14 feeding days. Methods: Primary outcome was days to full enteral feeding (≥140 mL/kg/day). Per protocol analyses included the following: all participants who met study entrance criteria and completed study feeding (primary) and those who received ≥75% enteral intake from study formula (subset). Mothers were encouraged to provide their breast milk. Results: Of the 65 enrolled (IPF: n = 32; EHF: n = 33), 60 completed study feeding per protocol (IPF: n = 30; EHF: n = 30), 37 (62%) received predominantly breast milk, and 23 (38%) received ≥75% study formula intake (IPF: n = 11; EHF: n = 12). No group differences were detected in tolerance measures. No necrotizing enterocolitis (NEC) was reported. Median time to achievement of full enteral feeding was significantly shorter for the IPF vs. EHF group (day 10 vs. 14, p < 0.05) (subset analysis). Mean enteral intake significantly increased by day 14 for the IPF group (p < 0.05), reflecting group divergence as achieved feeding volumes increased. Conclusions: Results suggest shorter time to full enteral feeding and higher feeding volume achieved by study end in preterm infants receiving intact protein preterm formula versus extensively hydrolyzed formula. |
format | Online Article Text |
id | pubmed-6720977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67209772019-09-10 Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial Baldassarre, Maria Elisabetta Di Mauro, Antonio Fanelli, Margherita Capozza, Manuela Wampler, Jennifer L. Cooper, Timothy Laforgia, Nicola Int J Environ Res Public Health Article Background: This study was carried out to evaluate enteral feeding advancement and tolerance in preterm infants receiving one of two marketed formulas: intact protein preterm formula (IPF) or extensively hydrolyzed formula (EHF) for the first 14 feeding days. Methods: Primary outcome was days to full enteral feeding (≥140 mL/kg/day). Per protocol analyses included the following: all participants who met study entrance criteria and completed study feeding (primary) and those who received ≥75% enteral intake from study formula (subset). Mothers were encouraged to provide their breast milk. Results: Of the 65 enrolled (IPF: n = 32; EHF: n = 33), 60 completed study feeding per protocol (IPF: n = 30; EHF: n = 30), 37 (62%) received predominantly breast milk, and 23 (38%) received ≥75% study formula intake (IPF: n = 11; EHF: n = 12). No group differences were detected in tolerance measures. No necrotizing enterocolitis (NEC) was reported. Median time to achievement of full enteral feeding was significantly shorter for the IPF vs. EHF group (day 10 vs. 14, p < 0.05) (subset analysis). Mean enteral intake significantly increased by day 14 for the IPF group (p < 0.05), reflecting group divergence as achieved feeding volumes increased. Conclusions: Results suggest shorter time to full enteral feeding and higher feeding volume achieved by study end in preterm infants receiving intact protein preterm formula versus extensively hydrolyzed formula. MDPI 2019-08-14 2019-08 /pmc/articles/PMC6720977/ /pubmed/31416171 http://dx.doi.org/10.3390/ijerph16162911 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Baldassarre, Maria Elisabetta Di Mauro, Antonio Fanelli, Margherita Capozza, Manuela Wampler, Jennifer L. Cooper, Timothy Laforgia, Nicola Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial |
title | Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial |
title_full | Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial |
title_fullStr | Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial |
title_full_unstemmed | Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial |
title_short | Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial |
title_sort | shorter time to full preterm feeding using intact protein formula: a randomized controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720977/ https://www.ncbi.nlm.nih.gov/pubmed/31416171 http://dx.doi.org/10.3390/ijerph16162911 |
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