Cargando…
Association of Environmental Features and the Risk of Alzheimer’s Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study
Little is known about the association between environmental features and the risk of Alzheimer’s dementia (AD). This study aims to investigate the association of physical and social environments with the incidence of AD. We identified 12,401 newly diagnosed AD cases aged ≥65 years in 2010, with the...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721060/ https://www.ncbi.nlm.nih.gov/pubmed/31398817 http://dx.doi.org/10.3390/ijerph16162828 |
_version_ | 1783448262155436032 |
---|---|
author | Liu, Chih-Ching Li, Chung-Yi Kung, Shiann-Far Kuo, Hsien-Wen Huang, Nuan-Ching Sun, Yu Hu, Susan C. |
author_facet | Liu, Chih-Ching Li, Chung-Yi Kung, Shiann-Far Kuo, Hsien-Wen Huang, Nuan-Ching Sun, Yu Hu, Susan C. |
author_sort | Liu, Chih-Ching |
collection | PubMed |
description | Little is known about the association between environmental features and the risk of Alzheimer’s dementia (AD). This study aims to investigate the association of physical and social environments with the incidence of AD. We identified 12,401 newly diagnosed AD cases aged ≥65 years in 2010, with the same no. of matched controls from National Health Insurance claims in Taiwan. Environmental data were collected from government statistics including three physical environments and three social environments. Multilevel logistic regression was conducted to calculate the odds ratios (OR) of AD in association with environmental features at the township level. Results showed that living in the areas with higher availability of playgrounds and sport venues was associated with a 3% decreased odds of AD (95% CI = 0.96–0.99), while higher density of elderly living alone was associated with a 5% increased odds of AD (95% CI = 1.01–1.11), after controlling for individual and other environmental factors. In further examination by urbanization level, the above relationships were found only in rural areas but not in urban areas. This study provides evidence that specific physical and social environmental features have different impacts on the risk of AD. |
format | Online Article Text |
id | pubmed-6721060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67210602019-09-10 Association of Environmental Features and the Risk of Alzheimer’s Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study Liu, Chih-Ching Li, Chung-Yi Kung, Shiann-Far Kuo, Hsien-Wen Huang, Nuan-Ching Sun, Yu Hu, Susan C. Int J Environ Res Public Health Article Little is known about the association between environmental features and the risk of Alzheimer’s dementia (AD). This study aims to investigate the association of physical and social environments with the incidence of AD. We identified 12,401 newly diagnosed AD cases aged ≥65 years in 2010, with the same no. of matched controls from National Health Insurance claims in Taiwan. Environmental data were collected from government statistics including three physical environments and three social environments. Multilevel logistic regression was conducted to calculate the odds ratios (OR) of AD in association with environmental features at the township level. Results showed that living in the areas with higher availability of playgrounds and sport venues was associated with a 3% decreased odds of AD (95% CI = 0.96–0.99), while higher density of elderly living alone was associated with a 5% increased odds of AD (95% CI = 1.01–1.11), after controlling for individual and other environmental factors. In further examination by urbanization level, the above relationships were found only in rural areas but not in urban areas. This study provides evidence that specific physical and social environmental features have different impacts on the risk of AD. MDPI 2019-08-08 2019-08 /pmc/articles/PMC6721060/ /pubmed/31398817 http://dx.doi.org/10.3390/ijerph16162828 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Chih-Ching Li, Chung-Yi Kung, Shiann-Far Kuo, Hsien-Wen Huang, Nuan-Ching Sun, Yu Hu, Susan C. Association of Environmental Features and the Risk of Alzheimer’s Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study |
title | Association of Environmental Features and the Risk of Alzheimer’s Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study |
title_full | Association of Environmental Features and the Risk of Alzheimer’s Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study |
title_fullStr | Association of Environmental Features and the Risk of Alzheimer’s Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study |
title_full_unstemmed | Association of Environmental Features and the Risk of Alzheimer’s Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study |
title_short | Association of Environmental Features and the Risk of Alzheimer’s Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study |
title_sort | association of environmental features and the risk of alzheimer’s dementia in older adults: a nationwide longitudinal case-control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721060/ https://www.ncbi.nlm.nih.gov/pubmed/31398817 http://dx.doi.org/10.3390/ijerph16162828 |
work_keys_str_mv | AT liuchihching associationofenvironmentalfeaturesandtheriskofalzheimersdementiainolderadultsanationwidelongitudinalcasecontrolstudy AT lichungyi associationofenvironmentalfeaturesandtheriskofalzheimersdementiainolderadultsanationwidelongitudinalcasecontrolstudy AT kungshiannfar associationofenvironmentalfeaturesandtheriskofalzheimersdementiainolderadultsanationwidelongitudinalcasecontrolstudy AT kuohsienwen associationofenvironmentalfeaturesandtheriskofalzheimersdementiainolderadultsanationwidelongitudinalcasecontrolstudy AT huangnuanching associationofenvironmentalfeaturesandtheriskofalzheimersdementiainolderadultsanationwidelongitudinalcasecontrolstudy AT sunyu associationofenvironmentalfeaturesandtheriskofalzheimersdementiainolderadultsanationwidelongitudinalcasecontrolstudy AT hususanc associationofenvironmentalfeaturesandtheriskofalzheimersdementiainolderadultsanationwidelongitudinalcasecontrolstudy |