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Post orgasmic illness syndrome: what do we know till now?
BACKGROUND: Peri orgasmic dysfunctions are very rare and little information exists on their diagnosis and treatment. One of these conditions is post-orgasmic illness syndrome (POIS), manifesting by a debilitating cluster of symptoms affecting men within seconds, minutes, or hours after ejaculation....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721082/ https://www.ncbi.nlm.nih.gov/pubmed/31508233 http://dx.doi.org/10.1186/s12610-019-0093-7 |
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author | Abdessater, Maher Elias, Sandra Mikhael, Elie Alhammadi, Abdalla Beley, Sebastien |
author_facet | Abdessater, Maher Elias, Sandra Mikhael, Elie Alhammadi, Abdalla Beley, Sebastien |
author_sort | Abdessater, Maher |
collection | PubMed |
description | BACKGROUND: Peri orgasmic dysfunctions are very rare and little information exists on their diagnosis and treatment. One of these conditions is post-orgasmic illness syndrome (POIS), manifesting by a debilitating cluster of symptoms affecting men within seconds, minutes, or hours after ejaculation. The aim of this article is to do a thorough literature review about POIS, in order to elucidate the pathophysiology, the diagnosis and the management of this rare disease. RESULTS: Updated literature review on Pubmed was done, using the following terms: “orgasm illness”, “post-orgasmic” and “postorgasmic illness syndrome”. The references of the 17 identified publications were also reviewed for additional 8 relevant articles that were all included in the results. POIS has 5 preliminary diagnostic criteria and criterion 1 has 7 described clusters. Pathophysiological hypotheses include: immunological phenomenon (most relevant), opioid-like withdrawal, neuroendocrine response, transient deregulation of the autonomic nervous system, hypersensitivity and disordered cytokines. Differential diagnoses include: chronic prostatitis, orgasmolepsy, benign orgasmic cephalgia, sneezing and rhinorrhea, postcoital dysphoria, post-coital asthma and rhinitis. Patients have been symptomatically treated with antihistamines, non-steroidal anti-inflammatory drugs, selective serotonin reuptake inhibitors, and benzodiazepines. A trial of hyposensitization therapy with autologous semen was successful. CONCLUSION: POIS is a rare condition that is underdiagnosed, most probably because of its unclear pathophysiology leading to a lack of treatment options. Further studies are warranted to investigate the prevalence, pathophysiology, and management of this debilitating condition. |
format | Online Article Text |
id | pubmed-6721082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67210822019-09-10 Post orgasmic illness syndrome: what do we know till now? Abdessater, Maher Elias, Sandra Mikhael, Elie Alhammadi, Abdalla Beley, Sebastien Basic Clin Androl Review Article BACKGROUND: Peri orgasmic dysfunctions are very rare and little information exists on their diagnosis and treatment. One of these conditions is post-orgasmic illness syndrome (POIS), manifesting by a debilitating cluster of symptoms affecting men within seconds, minutes, or hours after ejaculation. The aim of this article is to do a thorough literature review about POIS, in order to elucidate the pathophysiology, the diagnosis and the management of this rare disease. RESULTS: Updated literature review on Pubmed was done, using the following terms: “orgasm illness”, “post-orgasmic” and “postorgasmic illness syndrome”. The references of the 17 identified publications were also reviewed for additional 8 relevant articles that were all included in the results. POIS has 5 preliminary diagnostic criteria and criterion 1 has 7 described clusters. Pathophysiological hypotheses include: immunological phenomenon (most relevant), opioid-like withdrawal, neuroendocrine response, transient deregulation of the autonomic nervous system, hypersensitivity and disordered cytokines. Differential diagnoses include: chronic prostatitis, orgasmolepsy, benign orgasmic cephalgia, sneezing and rhinorrhea, postcoital dysphoria, post-coital asthma and rhinitis. Patients have been symptomatically treated with antihistamines, non-steroidal anti-inflammatory drugs, selective serotonin reuptake inhibitors, and benzodiazepines. A trial of hyposensitization therapy with autologous semen was successful. CONCLUSION: POIS is a rare condition that is underdiagnosed, most probably because of its unclear pathophysiology leading to a lack of treatment options. Further studies are warranted to investigate the prevalence, pathophysiology, and management of this debilitating condition. BioMed Central 2019-09-03 /pmc/articles/PMC6721082/ /pubmed/31508233 http://dx.doi.org/10.1186/s12610-019-0093-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Article Abdessater, Maher Elias, Sandra Mikhael, Elie Alhammadi, Abdalla Beley, Sebastien Post orgasmic illness syndrome: what do we know till now? |
title | Post orgasmic illness syndrome: what do we know till now? |
title_full | Post orgasmic illness syndrome: what do we know till now? |
title_fullStr | Post orgasmic illness syndrome: what do we know till now? |
title_full_unstemmed | Post orgasmic illness syndrome: what do we know till now? |
title_short | Post orgasmic illness syndrome: what do we know till now? |
title_sort | post orgasmic illness syndrome: what do we know till now? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721082/ https://www.ncbi.nlm.nih.gov/pubmed/31508233 http://dx.doi.org/10.1186/s12610-019-0093-7 |
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