Integrating expert opinion with clinical trial data to extrapolate long-term survival: a case study of CAR-T therapy for children and young adults with relapsed or refractory acute lymphoblastic leukemia

BACKGROUND: Long-term clinical outcomes are necessary to assess the cost-effectiveness of new treatments over a lifetime horizon. Without long-term clinical trial data, current practice to extrapolate survival beyond the trial period involves fitting alternative parametric models to the observed sur...

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Detalles Bibliográficos
Autores principales: Cope, Shannon, Ayers, Dieter, Zhang, Jie, Batt, Katharine, Jansen, Jeroen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721254/
https://www.ncbi.nlm.nih.gov/pubmed/31477025
http://dx.doi.org/10.1186/s12874-019-0823-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721254/
https://www.ncbi.nlm.nih.gov/pubmed/31477025
http://dx.doi.org/10.1186/s12874-019-0823-8

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