Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project

The Cancer Genome Atlas (TCGA) uveal melanoma project was a comprehensive multi-platform deep molecular investigation of 80 uveal melanoma primary tissue samples supported by the National Cancer Institute. In addition to identification of important mutations for the first time, it identified four di...

Descripción completa

Detalles Bibliográficos
Autores principales: Bakhoum, Mathieu F., Esmaeli, Bita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721321/
https://www.ncbi.nlm.nih.gov/pubmed/31357599
http://dx.doi.org/10.3390/cancers11081061
_version_ 1783448318092771328
author Bakhoum, Mathieu F.
Esmaeli, Bita
author_facet Bakhoum, Mathieu F.
Esmaeli, Bita
author_sort Bakhoum, Mathieu F.
collection PubMed
description The Cancer Genome Atlas (TCGA) uveal melanoma project was a comprehensive multi-platform deep molecular investigation of 80 uveal melanoma primary tissue samples supported by the National Cancer Institute. In addition to identification of important mutations for the first time, it identified four different clusters (subgroups) of patients paralleling prognosis. The findings of the TCGA marker paper are summarized in this review manuscript and other investigations that have stemmed from the findings of the TCGA project are reviewed.
format Online
Article
Text
id pubmed-6721321
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67213212019-09-10 Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project Bakhoum, Mathieu F. Esmaeli, Bita Cancers (Basel) Review The Cancer Genome Atlas (TCGA) uveal melanoma project was a comprehensive multi-platform deep molecular investigation of 80 uveal melanoma primary tissue samples supported by the National Cancer Institute. In addition to identification of important mutations for the first time, it identified four different clusters (subgroups) of patients paralleling prognosis. The findings of the TCGA marker paper are summarized in this review manuscript and other investigations that have stemmed from the findings of the TCGA project are reviewed. MDPI 2019-07-27 /pmc/articles/PMC6721321/ /pubmed/31357599 http://dx.doi.org/10.3390/cancers11081061 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bakhoum, Mathieu F.
Esmaeli, Bita
Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project
title Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project
title_full Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project
title_fullStr Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project
title_full_unstemmed Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project
title_short Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project
title_sort molecular characteristics of uveal melanoma: insights from the cancer genome atlas (tcga) project
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721321/
https://www.ncbi.nlm.nih.gov/pubmed/31357599
http://dx.doi.org/10.3390/cancers11081061
work_keys_str_mv AT bakhoummathieuf molecularcharacteristicsofuvealmelanomainsightsfromthecancergenomeatlastcgaproject
AT esmaelibita molecularcharacteristicsofuvealmelanomainsightsfromthecancergenomeatlastcgaproject

Ejemplares similares