4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters

BACKGROUND: The alteration of lipid metabolism in cancer cells is recognized as one of the most important metabolic hallmarks of cancer. Membrane rafts defined as plasma membrane microdomains enriched in cholesterol and sphingolipids serve as platforms for signaling regulation in cancer. The main pu...

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Detalles Bibliográficos
Autores principales: Elia, Josiane, Carbonnelle, Delphine, Logé, Cédric, Ory, Lucie, Huvelin, Jean-Michel, Tannoury, Mona, Diab-Assaf, Mona, Petit, Karina, Nazih, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721338/
https://www.ncbi.nlm.nih.gov/pubmed/31477154
http://dx.doi.org/10.1186/s12944-019-1103-7

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