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Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy?
No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immu...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721347/ https://www.ncbi.nlm.nih.gov/pubmed/31357439 http://dx.doi.org/10.3390/cancers11081055 |
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| author | Rossi, Ernesto Schinzari, Giovanni Zizzari, Ilaria Grazia Maiorano, Brigida Anna Pagliara, Monica Maria Sammarco, Maria Grazia Fiorentino, Vincenzo Petrone, Gianluigi Cassano, Alessandra Rindi, Guido Bria, Emilio Blasi, Maria Antonietta Nuti, Marianna Tortora, Giampaolo |
| author_facet | Rossi, Ernesto Schinzari, Giovanni Zizzari, Ilaria Grazia Maiorano, Brigida Anna Pagliara, Monica Maria Sammarco, Maria Grazia Fiorentino, Vincenzo Petrone, Gianluigi Cassano, Alessandra Rindi, Guido Bria, Emilio Blasi, Maria Antonietta Nuti, Marianna Tortora, Giampaolo |
| author_sort | Rossi, Ernesto |
| collection | PubMed |
| description | No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immunotherapy. The immunological features of mUM were reviewed in order to understand if immunotherapy could still play a role for this disease. |
| format | Online Article Text |
| id | pubmed-6721347 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67213472019-09-10 Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? Rossi, Ernesto Schinzari, Giovanni Zizzari, Ilaria Grazia Maiorano, Brigida Anna Pagliara, Monica Maria Sammarco, Maria Grazia Fiorentino, Vincenzo Petrone, Gianluigi Cassano, Alessandra Rindi, Guido Bria, Emilio Blasi, Maria Antonietta Nuti, Marianna Tortora, Giampaolo Cancers (Basel) Review No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immunotherapy. The immunological features of mUM were reviewed in order to understand if immunotherapy could still play a role for this disease. MDPI 2019-07-26 /pmc/articles/PMC6721347/ /pubmed/31357439 http://dx.doi.org/10.3390/cancers11081055 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Rossi, Ernesto Schinzari, Giovanni Zizzari, Ilaria Grazia Maiorano, Brigida Anna Pagliara, Monica Maria Sammarco, Maria Grazia Fiorentino, Vincenzo Petrone, Gianluigi Cassano, Alessandra Rindi, Guido Bria, Emilio Blasi, Maria Antonietta Nuti, Marianna Tortora, Giampaolo Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? |
| title | Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? |
| title_full | Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? |
| title_fullStr | Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? |
| title_full_unstemmed | Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? |
| title_short | Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy? |
| title_sort | immunological backbone of uveal melanoma: is there a rationale for immunotherapy? |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721347/ https://www.ncbi.nlm.nih.gov/pubmed/31357439 http://dx.doi.org/10.3390/cancers11081055 |
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