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Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response

The auditory steady-state response (ASSR) elicited by a periodic sound stimulus is a neural oscillation recorded by magnetoencephalography (MEG), which is phase-locked to the repeated sound stimuli. This ASSR phase alternates after an abrupt change in the feature of a periodic sound stimulus and ret...

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Autores principales: Motomura, Eishi, Inui, Koji, Kawano, Yasuhiro, Nishihara, Makoto, Okada, Motohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721352/
https://www.ncbi.nlm.nih.gov/pubmed/31426410
http://dx.doi.org/10.3390/brainsci9080203
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author Motomura, Eishi
Inui, Koji
Kawano, Yasuhiro
Nishihara, Makoto
Okada, Motohiro
author_facet Motomura, Eishi
Inui, Koji
Kawano, Yasuhiro
Nishihara, Makoto
Okada, Motohiro
author_sort Motomura, Eishi
collection PubMed
description The auditory steady-state response (ASSR) elicited by a periodic sound stimulus is a neural oscillation recorded by magnetoencephalography (MEG), which is phase-locked to the repeated sound stimuli. This ASSR phase alternates after an abrupt change in the feature of a periodic sound stimulus and returns to its steady-state value. An abrupt change also elicits a MEG component peaking at approximately 100–180 ms (called “Change-N1m”). We investigated whether both the ASSR phase deviation and Change-N1m were affected by the magnitude of change in sound pressure. The ASSR and Change-N1m to 40 Hz click-trains (1000 ms duration, 70 dB), with and without an abrupt change (± 5, ± 10, or ± 15 dB) were recorded in ten healthy subjects. We used the source strength waveforms obtained by a two-dipole model for measurement of the ASSR phase deviation and Change-N1m values (peak amplitude and latency). As the magnitude of change increased, Change-N1m increased in amplitude and decreased in latency. Similarly, ASSR phase deviation depended on the magnitude of sound-pressure change. Thus, we suspect that both Change-N1m and the ASSR phase deviation reflect the sensitivity of the brain’s neural change-detection system.
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spelling pubmed-67213522019-09-10 Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response Motomura, Eishi Inui, Koji Kawano, Yasuhiro Nishihara, Makoto Okada, Motohiro Brain Sci Article The auditory steady-state response (ASSR) elicited by a periodic sound stimulus is a neural oscillation recorded by magnetoencephalography (MEG), which is phase-locked to the repeated sound stimuli. This ASSR phase alternates after an abrupt change in the feature of a periodic sound stimulus and returns to its steady-state value. An abrupt change also elicits a MEG component peaking at approximately 100–180 ms (called “Change-N1m”). We investigated whether both the ASSR phase deviation and Change-N1m were affected by the magnitude of change in sound pressure. The ASSR and Change-N1m to 40 Hz click-trains (1000 ms duration, 70 dB), with and without an abrupt change (± 5, ± 10, or ± 15 dB) were recorded in ten healthy subjects. We used the source strength waveforms obtained by a two-dipole model for measurement of the ASSR phase deviation and Change-N1m values (peak amplitude and latency). As the magnitude of change increased, Change-N1m increased in amplitude and decreased in latency. Similarly, ASSR phase deviation depended on the magnitude of sound-pressure change. Thus, we suspect that both Change-N1m and the ASSR phase deviation reflect the sensitivity of the brain’s neural change-detection system. MDPI 2019-08-16 /pmc/articles/PMC6721352/ /pubmed/31426410 http://dx.doi.org/10.3390/brainsci9080203 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Motomura, Eishi
Inui, Koji
Kawano, Yasuhiro
Nishihara, Makoto
Okada, Motohiro
Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response
title Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response
title_full Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response
title_fullStr Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response
title_full_unstemmed Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response
title_short Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response
title_sort effects of sound-pressure change on the 40 hz auditory steady-state response and change-related cerebral response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721352/
https://www.ncbi.nlm.nih.gov/pubmed/31426410
http://dx.doi.org/10.3390/brainsci9080203
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