Cargando…

Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy

Thrombocytopenia is one of the most common hematological abnormalities observed during pregnancy, and in rare cases, this may be the first indicator of an underlying hematological malignancy. Hairy cell leukemia (HCL) is an uncommon B-cell lymphoproliferative disorder of which thrombocytopenia is a...

Descripción completa

Detalles Bibliográficos
Autores principales: Shackleton, Louisa, Langabeer, Stephen E., O'Brien, David, McCarron, Sarah L., Byrne, Bridgette, Barry, Rupert, Flavin, Richard, Bacon, C. Larry, Flynn, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721453/
https://www.ncbi.nlm.nih.gov/pubmed/31531250
http://dx.doi.org/10.1155/2019/3238168
_version_ 1783448346207191040
author Shackleton, Louisa
Langabeer, Stephen E.
O'Brien, David
McCarron, Sarah L.
Byrne, Bridgette
Barry, Rupert
Flavin, Richard
Bacon, C. Larry
Flynn, Catherine M.
author_facet Shackleton, Louisa
Langabeer, Stephen E.
O'Brien, David
McCarron, Sarah L.
Byrne, Bridgette
Barry, Rupert
Flavin, Richard
Bacon, C. Larry
Flynn, Catherine M.
author_sort Shackleton, Louisa
collection PubMed
description Thrombocytopenia is one of the most common hematological abnormalities observed during pregnancy, and in rare cases, this may be the first indicator of an underlying hematological malignancy. Hairy cell leukemia (HCL) is an uncommon B-cell lymphoproliferative disorder of which thrombocytopenia is a recurrent presenting feature. A case of pancytopenia presenting in pregnancy is described in which the thrombocytopenia persisted postpartum coincidental with a vesicular, pustular rash characterised as Sweet's syndrome. Hematological, histological, immunophenotypic, and molecular investigations confirmed the presence of HCL. The patient was treated with cladribine resulting in resolution of Sweet's syndrome, hematological remission from HCL, and achievement of a normal platelet count. This case highlights the need to maintain a wide differential diagnosis for presentations of pancytopenia or thrombocytopenia in pregnancy and the requirement for follow-up investigation of unusual cases with a lack of response to steroids or immunoglobulin.
format Online
Article
Text
id pubmed-6721453
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-67214532019-09-17 Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy Shackleton, Louisa Langabeer, Stephen E. O'Brien, David McCarron, Sarah L. Byrne, Bridgette Barry, Rupert Flavin, Richard Bacon, C. Larry Flynn, Catherine M. Case Rep Hematol Case Report Thrombocytopenia is one of the most common hematological abnormalities observed during pregnancy, and in rare cases, this may be the first indicator of an underlying hematological malignancy. Hairy cell leukemia (HCL) is an uncommon B-cell lymphoproliferative disorder of which thrombocytopenia is a recurrent presenting feature. A case of pancytopenia presenting in pregnancy is described in which the thrombocytopenia persisted postpartum coincidental with a vesicular, pustular rash characterised as Sweet's syndrome. Hematological, histological, immunophenotypic, and molecular investigations confirmed the presence of HCL. The patient was treated with cladribine resulting in resolution of Sweet's syndrome, hematological remission from HCL, and achievement of a normal platelet count. This case highlights the need to maintain a wide differential diagnosis for presentations of pancytopenia or thrombocytopenia in pregnancy and the requirement for follow-up investigation of unusual cases with a lack of response to steroids or immunoglobulin. Hindawi 2019-08-21 /pmc/articles/PMC6721453/ /pubmed/31531250 http://dx.doi.org/10.1155/2019/3238168 Text en Copyright © 2019 Louisa Shackleton et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shackleton, Louisa
Langabeer, Stephen E.
O'Brien, David
McCarron, Sarah L.
Byrne, Bridgette
Barry, Rupert
Flavin, Richard
Bacon, C. Larry
Flynn, Catherine M.
Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy
title Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy
title_full Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy
title_fullStr Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy
title_full_unstemmed Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy
title_short Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy
title_sort hairy cell leukemia masquerading as pancytopenia in pregnancy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721453/
https://www.ncbi.nlm.nih.gov/pubmed/31531250
http://dx.doi.org/10.1155/2019/3238168
work_keys_str_mv AT shackletonlouisa hairycellleukemiamasqueradingaspancytopeniainpregnancy
AT langabeerstephene hairycellleukemiamasqueradingaspancytopeniainpregnancy
AT obriendavid hairycellleukemiamasqueradingaspancytopeniainpregnancy
AT mccarronsarahl hairycellleukemiamasqueradingaspancytopeniainpregnancy
AT byrnebridgette hairycellleukemiamasqueradingaspancytopeniainpregnancy
AT barryrupert hairycellleukemiamasqueradingaspancytopeniainpregnancy
AT flavinrichard hairycellleukemiamasqueradingaspancytopeniainpregnancy
AT baconclarry hairycellleukemiamasqueradingaspancytopeniainpregnancy
AT flynncatherinem hairycellleukemiamasqueradingaspancytopeniainpregnancy