Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight

The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed,...

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Autores principales: Lamort, Anne-Sophie, Giopanou, Ioanna, Psallidas, Ioannis, Stathopoulos, Georgios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721491/
https://www.ncbi.nlm.nih.gov/pubmed/31382483
http://dx.doi.org/10.3390/cells8080815
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author Lamort, Anne-Sophie
Giopanou, Ioanna
Psallidas, Ioannis
Stathopoulos, Georgios T.
author_facet Lamort, Anne-Sophie
Giopanou, Ioanna
Psallidas, Ioannis
Stathopoulos, Georgios T.
author_sort Lamort, Anne-Sophie
collection PubMed
description The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.
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spelling pubmed-67214912019-09-10 Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight Lamort, Anne-Sophie Giopanou, Ioanna Psallidas, Ioannis Stathopoulos, Georgios T. Cells Review The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples. MDPI 2019-08-02 /pmc/articles/PMC6721491/ /pubmed/31382483 http://dx.doi.org/10.3390/cells8080815 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lamort, Anne-Sophie
Giopanou, Ioanna
Psallidas, Ioannis
Stathopoulos, Georgios T.
Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
title Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
title_full Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
title_fullStr Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
title_full_unstemmed Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
title_short Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
title_sort osteopontin as a link between inflammation and cancer: the thorax in the spotlight
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721491/
https://www.ncbi.nlm.nih.gov/pubmed/31382483
http://dx.doi.org/10.3390/cells8080815
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