SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis

The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties...

Descripción completa

Detalles Bibliográficos
Autores principales: Batham, Jacob, Lim, Pek Siew, Rao, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721492/
https://www.ncbi.nlm.nih.gov/pubmed/31405032
http://dx.doi.org/10.3390/cancers11081143
_version_ 1783448355438854144
author Batham, Jacob
Lim, Pek Siew
Rao, Sudha
author_facet Batham, Jacob
Lim, Pek Siew
Rao, Sudha
author_sort Batham, Jacob
collection PubMed
description The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelial-to-mesenchymal transition and confer resistance to therapies.
format Online
Article
Text
id pubmed-6721492
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67214922019-09-10 SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis Batham, Jacob Lim, Pek Siew Rao, Sudha Cancers (Basel) Review The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelial-to-mesenchymal transition and confer resistance to therapies. MDPI 2019-08-09 /pmc/articles/PMC6721492/ /pubmed/31405032 http://dx.doi.org/10.3390/cancers11081143 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Batham, Jacob
Lim, Pek Siew
Rao, Sudha
SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
title SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
title_full SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
title_fullStr SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
title_full_unstemmed SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
title_short SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
title_sort setdb-1: a potential epigenetic regulator in breast cancer metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721492/
https://www.ncbi.nlm.nih.gov/pubmed/31405032
http://dx.doi.org/10.3390/cancers11081143
work_keys_str_mv AT bathamjacob setdb1apotentialepigeneticregulatorinbreastcancermetastasis
AT limpeksiew setdb1apotentialepigeneticregulatorinbreastcancermetastasis
AT raosudha setdb1apotentialepigeneticregulatorinbreastcancermetastasis

Ejemplares similares