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Mesenchymal Stem Cell Migration and Tissue Repair

Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell the...

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Autores principales: Fu, Xiaorong, Liu, Ge, Halim, Alexander, Ju, Yang, Luo, Qing, Song, Guanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721499/
https://www.ncbi.nlm.nih.gov/pubmed/31357692
http://dx.doi.org/10.3390/cells8080784
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author Fu, Xiaorong
Liu, Ge
Halim, Alexander
Ju, Yang
Luo, Qing
Song, Guanbin
author_facet Fu, Xiaorong
Liu, Ge
Halim, Alexander
Ju, Yang
Luo, Qing
Song, Guanbin
author_sort Fu, Xiaorong
collection PubMed
description Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell therapy and tissue engineering. However, it is prerequisite for BMSCs to mobilize from bone marrow and migrate into injured tissues during the healing process, through peripheral circulation. The migration of BMSCs is regulated by mechanical and chemical factors in this trafficking process. In this paper, we review the effects of several main regulatory factors on BMSC migration and its underlying mechanism; discuss two critical roles of BMSCs—namely, directed differentiation and the paracrine function—in tissue repair; and provide insight into the relationship between BMSC migration and tissue repair, which may provide a better guide for clinical applications in tissue repair through the efficient regulation of BMSC migration.
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spelling pubmed-67214992019-09-10 Mesenchymal Stem Cell Migration and Tissue Repair Fu, Xiaorong Liu, Ge Halim, Alexander Ju, Yang Luo, Qing Song, Guanbin Cells Review Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell therapy and tissue engineering. However, it is prerequisite for BMSCs to mobilize from bone marrow and migrate into injured tissues during the healing process, through peripheral circulation. The migration of BMSCs is regulated by mechanical and chemical factors in this trafficking process. In this paper, we review the effects of several main regulatory factors on BMSC migration and its underlying mechanism; discuss two critical roles of BMSCs—namely, directed differentiation and the paracrine function—in tissue repair; and provide insight into the relationship between BMSC migration and tissue repair, which may provide a better guide for clinical applications in tissue repair through the efficient regulation of BMSC migration. MDPI 2019-07-28 /pmc/articles/PMC6721499/ /pubmed/31357692 http://dx.doi.org/10.3390/cells8080784 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fu, Xiaorong
Liu, Ge
Halim, Alexander
Ju, Yang
Luo, Qing
Song, Guanbin
Mesenchymal Stem Cell Migration and Tissue Repair
title Mesenchymal Stem Cell Migration and Tissue Repair
title_full Mesenchymal Stem Cell Migration and Tissue Repair
title_fullStr Mesenchymal Stem Cell Migration and Tissue Repair
title_full_unstemmed Mesenchymal Stem Cell Migration and Tissue Repair
title_short Mesenchymal Stem Cell Migration and Tissue Repair
title_sort mesenchymal stem cell migration and tissue repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721499/
https://www.ncbi.nlm.nih.gov/pubmed/31357692
http://dx.doi.org/10.3390/cells8080784
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