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Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015
The present study aimed to clarify the incidence and clinical outcomes of nasopharyngeal carcinoma (NPC) in the Chubu region of Japan from 2006 to 2015, compared with previous reports. A retrospective analysis was conducted based on medical records from 40 hospitals located in the Chubu region in th...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721521/ https://www.ncbi.nlm.nih.gov/pubmed/31443218 http://dx.doi.org/10.3390/cancers11081180 |
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author | Kanno, Masafumi Narita, Norihiko Fujimoto, Yasushi Wakisaka, Naohiro Yoshizaki, Tomokazu Kodaira, Takeshi Makita, Chiyoko Sato, Yuichiro Yamazaki, Keisuke Wakaoka, Takanori Shimode, Yuzo Tsuji, Hiroyuki Kito, Ryosuke Ishinaga, Hajime Hosokawa, Seiji Takakura, Hiromasa Nishimura, Kunihiro Matoba, Takuma Fujieda, Shigeharu |
author_facet | Kanno, Masafumi Narita, Norihiko Fujimoto, Yasushi Wakisaka, Naohiro Yoshizaki, Tomokazu Kodaira, Takeshi Makita, Chiyoko Sato, Yuichiro Yamazaki, Keisuke Wakaoka, Takanori Shimode, Yuzo Tsuji, Hiroyuki Kito, Ryosuke Ishinaga, Hajime Hosokawa, Seiji Takakura, Hiromasa Nishimura, Kunihiro Matoba, Takuma Fujieda, Shigeharu |
author_sort | Kanno, Masafumi |
collection | PubMed |
description | The present study aimed to clarify the incidence and clinical outcomes of nasopharyngeal carcinoma (NPC) in the Chubu region of Japan from 2006 to 2015, compared with previous reports. A retrospective analysis was conducted based on medical records from 40 hospitals located in the Chubu region in the central Japanese main island, with a population of around 22.66 million individuals. This study was designed in line with to two previous clinical studies into NPC conducted in the same area of Japan. We recruited NPC patients diagnosed in hospitals across this area over a 10-year period (2006–2015) using a questionnaire about sex, age, primary site, clinical symptoms, pathology, Union for International Cancer Control (UICC) staging, serological exam, treatment, and survival. A total of 620 NPC patients were identified. The age-standardized incidence of NPC from 2006 to 2015 was 0.27 per 100,000 individuals per year. There were no significant differences between this study and the previous two studies conducted in the same area of Japan. The five-year overall survival rate for all patients was 75.9%, while those for patients with stages I, II, III, and IVA were 97%, 91%, 79%, and 68%, respectively. The age-standardized annual incidence of NPC in the present study was 0.27 per 100,000 individuals per year, which was relatively low and stable. The five-year overall survival rate for all NPC patients was significantly improved in this decade compared with previous studies. The smoking rates in male and female NPC patients were 64.5% and 18.8%, respectively, thereby suggesting the involvement of smoking in the incidence of NPC. |
format | Online Article Text |
id | pubmed-6721521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67215212019-09-10 Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015 Kanno, Masafumi Narita, Norihiko Fujimoto, Yasushi Wakisaka, Naohiro Yoshizaki, Tomokazu Kodaira, Takeshi Makita, Chiyoko Sato, Yuichiro Yamazaki, Keisuke Wakaoka, Takanori Shimode, Yuzo Tsuji, Hiroyuki Kito, Ryosuke Ishinaga, Hajime Hosokawa, Seiji Takakura, Hiromasa Nishimura, Kunihiro Matoba, Takuma Fujieda, Shigeharu Cancers (Basel) Article The present study aimed to clarify the incidence and clinical outcomes of nasopharyngeal carcinoma (NPC) in the Chubu region of Japan from 2006 to 2015, compared with previous reports. A retrospective analysis was conducted based on medical records from 40 hospitals located in the Chubu region in the central Japanese main island, with a population of around 22.66 million individuals. This study was designed in line with to two previous clinical studies into NPC conducted in the same area of Japan. We recruited NPC patients diagnosed in hospitals across this area over a 10-year period (2006–2015) using a questionnaire about sex, age, primary site, clinical symptoms, pathology, Union for International Cancer Control (UICC) staging, serological exam, treatment, and survival. A total of 620 NPC patients were identified. The age-standardized incidence of NPC from 2006 to 2015 was 0.27 per 100,000 individuals per year. There were no significant differences between this study and the previous two studies conducted in the same area of Japan. The five-year overall survival rate for all patients was 75.9%, while those for patients with stages I, II, III, and IVA were 97%, 91%, 79%, and 68%, respectively. The age-standardized annual incidence of NPC in the present study was 0.27 per 100,000 individuals per year, which was relatively low and stable. The five-year overall survival rate for all NPC patients was significantly improved in this decade compared with previous studies. The smoking rates in male and female NPC patients were 64.5% and 18.8%, respectively, thereby suggesting the involvement of smoking in the incidence of NPC. MDPI 2019-08-15 /pmc/articles/PMC6721521/ /pubmed/31443218 http://dx.doi.org/10.3390/cancers11081180 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kanno, Masafumi Narita, Norihiko Fujimoto, Yasushi Wakisaka, Naohiro Yoshizaki, Tomokazu Kodaira, Takeshi Makita, Chiyoko Sato, Yuichiro Yamazaki, Keisuke Wakaoka, Takanori Shimode, Yuzo Tsuji, Hiroyuki Kito, Ryosuke Ishinaga, Hajime Hosokawa, Seiji Takakura, Hiromasa Nishimura, Kunihiro Matoba, Takuma Fujieda, Shigeharu Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015 |
title | Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015 |
title_full | Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015 |
title_fullStr | Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015 |
title_full_unstemmed | Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015 |
title_short | Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015 |
title_sort | third epidemiological analysis of nasopharyngeal carcinoma in the central region of japan from 2006 to 2015 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721521/ https://www.ncbi.nlm.nih.gov/pubmed/31443218 http://dx.doi.org/10.3390/cancers11081180 |
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