HOX Genes in High Grade Ovarian Cancer

HOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. High grade ovarian cancer is the most lethal gynaecological malignancy. Our understanding of the role of HOX genes in the oncogenesis of ovarian cancer is evolving, and here...

Descripción completa

Detalles Bibliográficos
Autores principales: Idaikkadar, Praveena, Morgan, Richard, Michael, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721551/
https://www.ncbi.nlm.nih.gov/pubmed/31382546
http://dx.doi.org/10.3390/cancers11081107
_version_ 1783448369372332032
author Idaikkadar, Praveena
Morgan, Richard
Michael, Agnieszka
author_facet Idaikkadar, Praveena
Morgan, Richard
Michael, Agnieszka
author_sort Idaikkadar, Praveena
collection PubMed
description HOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. High grade ovarian cancer is the most lethal gynaecological malignancy. Our understanding of the role of HOX genes in the oncogenesis of ovarian cancer is evolving, and here we review their dysregulated expression patterns, their function in cell survival and invasion, their potential uses as biomarkers, and ways in which HOX genes are being targeted with new and existing drugs.
format Online
Article
Text
id pubmed-6721551
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67215512019-09-10 HOX Genes in High Grade Ovarian Cancer Idaikkadar, Praveena Morgan, Richard Michael, Agnieszka Cancers (Basel) Review HOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. High grade ovarian cancer is the most lethal gynaecological malignancy. Our understanding of the role of HOX genes in the oncogenesis of ovarian cancer is evolving, and here we review their dysregulated expression patterns, their function in cell survival and invasion, their potential uses as biomarkers, and ways in which HOX genes are being targeted with new and existing drugs. MDPI 2019-08-03 /pmc/articles/PMC6721551/ /pubmed/31382546 http://dx.doi.org/10.3390/cancers11081107 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Idaikkadar, Praveena
Morgan, Richard
Michael, Agnieszka
HOX Genes in High Grade Ovarian Cancer
title HOX Genes in High Grade Ovarian Cancer
title_full HOX Genes in High Grade Ovarian Cancer
title_fullStr HOX Genes in High Grade Ovarian Cancer
title_full_unstemmed HOX Genes in High Grade Ovarian Cancer
title_short HOX Genes in High Grade Ovarian Cancer
title_sort hox genes in high grade ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721551/
https://www.ncbi.nlm.nih.gov/pubmed/31382546
http://dx.doi.org/10.3390/cancers11081107
work_keys_str_mv AT idaikkadarpraveena hoxgenesinhighgradeovariancancer
AT morganrichard hoxgenesinhighgradeovariancancer
AT michaelagnieszka hoxgenesinhighgradeovariancancer

Ejemplares similares