Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

The importance of reactive oxygen species (ROS) has been gradually acknowledged over the last four decades. Initially perceived as unwanted products of detrimental oxidative stress, they have been upgraded since, and now ROS are also known to be essential for the regulation of physiological cellular...

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Detalles Bibliográficos
Autores principales: Milkovic, Lidija, Cipak Gasparovic, Ana, Cindric, Marina, Mouthuy, Pierre-Alexis, Zarkovic, Neven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721558/
https://www.ncbi.nlm.nih.gov/pubmed/31366062
http://dx.doi.org/10.3390/cells8080793
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author Milkovic, Lidija
Cipak Gasparovic, Ana
Cindric, Marina
Mouthuy, Pierre-Alexis
Zarkovic, Neven
author_facet Milkovic, Lidija
Cipak Gasparovic, Ana
Cindric, Marina
Mouthuy, Pierre-Alexis
Zarkovic, Neven
author_sort Milkovic, Lidija
collection PubMed
description The importance of reactive oxygen species (ROS) has been gradually acknowledged over the last four decades. Initially perceived as unwanted products of detrimental oxidative stress, they have been upgraded since, and now ROS are also known to be essential for the regulation of physiological cellular functions through redox signaling. In the majority of cases, metabolic demands, along with other stimuli, are vital for ROS formation and their actions. In this review, we focus on the role of ROS in regulating cell functioning and communication among themselves. The relevance of ROS in therapy concepts is also addressed here.
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spelling pubmed-67215582019-09-10 Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts Milkovic, Lidija Cipak Gasparovic, Ana Cindric, Marina Mouthuy, Pierre-Alexis Zarkovic, Neven Cells Review The importance of reactive oxygen species (ROS) has been gradually acknowledged over the last four decades. Initially perceived as unwanted products of detrimental oxidative stress, they have been upgraded since, and now ROS are also known to be essential for the regulation of physiological cellular functions through redox signaling. In the majority of cases, metabolic demands, along with other stimuli, are vital for ROS formation and their actions. In this review, we focus on the role of ROS in regulating cell functioning and communication among themselves. The relevance of ROS in therapy concepts is also addressed here. MDPI 2019-07-30 /pmc/articles/PMC6721558/ /pubmed/31366062 http://dx.doi.org/10.3390/cells8080793 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Milkovic, Lidija
Cipak Gasparovic, Ana
Cindric, Marina
Mouthuy, Pierre-Alexis
Zarkovic, Neven
Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
title Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
title_full Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
title_fullStr Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
title_full_unstemmed Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
title_short Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
title_sort short overview of ros as cell function regulators and their implications in therapy concepts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721558/
https://www.ncbi.nlm.nih.gov/pubmed/31366062
http://dx.doi.org/10.3390/cells8080793
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