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Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study

Abstract: (1) Background: To investigate the clinical outcomes between radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) for residual hepatocellular carcinoma (RHCC). (2) Methods: 139 patients were diagnosed with the RHCC after post-operative checkup, among whom 39 and 33 patie...

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Autores principales: Pan, Yang-Xun, Xi, Mian, Fu, Yi-Zhen, Hu, Dan-Dan, Wang, Jun-Cheng, Liu, Shi-Liang, Chen, Jin-Bin, Xu, Li, Zhou, Zhong-Guo, Liu, Meng-Zhong, Chen, Min-Shan, Zhao, Lei, Zhang, Yao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721575/
https://www.ncbi.nlm.nih.gov/pubmed/31387248
http://dx.doi.org/10.3390/cancers11081116
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author Pan, Yang-Xun
Xi, Mian
Fu, Yi-Zhen
Hu, Dan-Dan
Wang, Jun-Cheng
Liu, Shi-Liang
Chen, Jin-Bin
Xu, Li
Zhou, Zhong-Guo
Liu, Meng-Zhong
Chen, Min-Shan
Zhao, Lei
Zhang, Yao-Jun
author_facet Pan, Yang-Xun
Xi, Mian
Fu, Yi-Zhen
Hu, Dan-Dan
Wang, Jun-Cheng
Liu, Shi-Liang
Chen, Jin-Bin
Xu, Li
Zhou, Zhong-Guo
Liu, Meng-Zhong
Chen, Min-Shan
Zhao, Lei
Zhang, Yao-Jun
author_sort Pan, Yang-Xun
collection PubMed
description Abstract: (1) Background: To investigate the clinical outcomes between radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) for residual hepatocellular carcinoma (RHCC). (2) Methods: 139 patients were diagnosed with the RHCC after post-operative checkup, among whom 39 and 33 patients underwent RFA or SBRT as salvage treatments, respectively. We applied the propensity score matching (PSM) to adjust for imbalances in treatment assignment. Local disease progression, progression-free survival (PFS), overall survival (OS), and treatment-related side effects were the study endpoints. (3) Results: Before PSM, the SBRT group demonstrated significantly lower local disease progression rate (6/33 vs. 23/39; p = 0.002), better PFS (the 1- and 3-year PFS were 63.3% and 49.3% vs. 41.5% and 22.3%, respectively, p = 0.036), and comparable OS (the 1- and 3-year OS were 85.4% and 71.1% vs. 97.3% and 57.6%, respectively, p = 0.680). After PSM of 23 matched cases, the SBRT group demonstrated significantly lower local disease progression rate, better PFS and comparable OS. Centrally located tumor predicted the worse OS. No acute grade 3+ toxicity was observed in both groups. (4) Conclusion: SBRT might be the preferred treatment for RHCC, especially for patients with larger tumors or tumors abutting major vessels, rather than repeated RFA.
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spelling pubmed-67215752019-09-10 Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study Pan, Yang-Xun Xi, Mian Fu, Yi-Zhen Hu, Dan-Dan Wang, Jun-Cheng Liu, Shi-Liang Chen, Jin-Bin Xu, Li Zhou, Zhong-Guo Liu, Meng-Zhong Chen, Min-Shan Zhao, Lei Zhang, Yao-Jun Cancers (Basel) Communication Abstract: (1) Background: To investigate the clinical outcomes between radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) for residual hepatocellular carcinoma (RHCC). (2) Methods: 139 patients were diagnosed with the RHCC after post-operative checkup, among whom 39 and 33 patients underwent RFA or SBRT as salvage treatments, respectively. We applied the propensity score matching (PSM) to adjust for imbalances in treatment assignment. Local disease progression, progression-free survival (PFS), overall survival (OS), and treatment-related side effects were the study endpoints. (3) Results: Before PSM, the SBRT group demonstrated significantly lower local disease progression rate (6/33 vs. 23/39; p = 0.002), better PFS (the 1- and 3-year PFS were 63.3% and 49.3% vs. 41.5% and 22.3%, respectively, p = 0.036), and comparable OS (the 1- and 3-year OS were 85.4% and 71.1% vs. 97.3% and 57.6%, respectively, p = 0.680). After PSM of 23 matched cases, the SBRT group demonstrated significantly lower local disease progression rate, better PFS and comparable OS. Centrally located tumor predicted the worse OS. No acute grade 3+ toxicity was observed in both groups. (4) Conclusion: SBRT might be the preferred treatment for RHCC, especially for patients with larger tumors or tumors abutting major vessels, rather than repeated RFA. MDPI 2019-08-05 /pmc/articles/PMC6721575/ /pubmed/31387248 http://dx.doi.org/10.3390/cancers11081116 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Pan, Yang-Xun
Xi, Mian
Fu, Yi-Zhen
Hu, Dan-Dan
Wang, Jun-Cheng
Liu, Shi-Liang
Chen, Jin-Bin
Xu, Li
Zhou, Zhong-Guo
Liu, Meng-Zhong
Chen, Min-Shan
Zhao, Lei
Zhang, Yao-Jun
Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study
title Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study
title_full Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study
title_fullStr Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study
title_full_unstemmed Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study
title_short Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study
title_sort stereotactic body radiotherapy as a salvage therapy after incomplete radiofrequency ablation for hepatocellular carcinoma: a retrospective propensity score matching study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721575/
https://www.ncbi.nlm.nih.gov/pubmed/31387248
http://dx.doi.org/10.3390/cancers11081116
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