Cargando…

NF-κB Signaling in Ovarian Cancer

The NF-κB signaling pathway is a master and commander in ovarian cancer (OC) that promotes chemoresistance, cancer stem cell maintenance, metastasis and immune evasion. Many signaling pathways are dysregulated in OC and can activate NF-κB signaling through canonical or non-canonical pathways which h...

Descripción completa

Detalles Bibliográficos
Autores principales: Harrington, Brittney S., Annunziata, Christina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721592/
https://www.ncbi.nlm.nih.gov/pubmed/31443240
http://dx.doi.org/10.3390/cancers11081182
_version_ 1783448379068514304
author Harrington, Brittney S.
Annunziata, Christina M.
author_facet Harrington, Brittney S.
Annunziata, Christina M.
author_sort Harrington, Brittney S.
collection PubMed
description The NF-κB signaling pathway is a master and commander in ovarian cancer (OC) that promotes chemoresistance, cancer stem cell maintenance, metastasis and immune evasion. Many signaling pathways are dysregulated in OC and can activate NF-κB signaling through canonical or non-canonical pathways which have both overlapping and distinct roles in tumor progression. The activation of canonical NF-κB signaling has been well established for anti-apoptotic and immunomodulatory functions in response to the tumor microenvironment and the non-canonical pathway in cancer stem cell maintenance and tumor re-initiation. NF-κB activity in OC cells helps to create an immune-evasive environment and to attract infiltrating immune cells with tumor-promoting phenotypes, which in turn, drive constitutive NF-κB activation in OC cells to promote cell survival and metastasis. For these reasons, NF-κB is an attractive target in OC, but current strategies are limited and broad inhibition of this major signaling pathway in normal physiological and immunological functions may produce unwanted side effects. There are some promising pre-clinical outcomes from developing research to target and inhibit NF-κB only in the tumor-reinitiating cancer cell population of OC and concurrently activate canonical NF-κB signaling in immune cells to promote anti-tumor immunity.
format Online
Article
Text
id pubmed-6721592
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67215922019-09-10 NF-κB Signaling in Ovarian Cancer Harrington, Brittney S. Annunziata, Christina M. Cancers (Basel) Review The NF-κB signaling pathway is a master and commander in ovarian cancer (OC) that promotes chemoresistance, cancer stem cell maintenance, metastasis and immune evasion. Many signaling pathways are dysregulated in OC and can activate NF-κB signaling through canonical or non-canonical pathways which have both overlapping and distinct roles in tumor progression. The activation of canonical NF-κB signaling has been well established for anti-apoptotic and immunomodulatory functions in response to the tumor microenvironment and the non-canonical pathway in cancer stem cell maintenance and tumor re-initiation. NF-κB activity in OC cells helps to create an immune-evasive environment and to attract infiltrating immune cells with tumor-promoting phenotypes, which in turn, drive constitutive NF-κB activation in OC cells to promote cell survival and metastasis. For these reasons, NF-κB is an attractive target in OC, but current strategies are limited and broad inhibition of this major signaling pathway in normal physiological and immunological functions may produce unwanted side effects. There are some promising pre-clinical outcomes from developing research to target and inhibit NF-κB only in the tumor-reinitiating cancer cell population of OC and concurrently activate canonical NF-κB signaling in immune cells to promote anti-tumor immunity. MDPI 2019-08-15 /pmc/articles/PMC6721592/ /pubmed/31443240 http://dx.doi.org/10.3390/cancers11081182 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Harrington, Brittney S.
Annunziata, Christina M.
NF-κB Signaling in Ovarian Cancer
title NF-κB Signaling in Ovarian Cancer
title_full NF-κB Signaling in Ovarian Cancer
title_fullStr NF-κB Signaling in Ovarian Cancer
title_full_unstemmed NF-κB Signaling in Ovarian Cancer
title_short NF-κB Signaling in Ovarian Cancer
title_sort nf-κb signaling in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721592/
https://www.ncbi.nlm.nih.gov/pubmed/31443240
http://dx.doi.org/10.3390/cancers11081182
work_keys_str_mv AT harringtonbrittneys nfkbsignalinginovariancancer
AT annunziatachristinam nfkbsignalinginovariancancer