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Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma

Esophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy, with hitherto dismal clinical outcome. Genomic analyses of patient samples reveal a complex heterogeneous landscape for ESCC, which presents in both intertumor and intratumor forms, manifests at both genomic and epigeno...

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Detalles Bibliográficos
Autores principales: Lin, Lehang, Lin, De-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721624/
https://www.ncbi.nlm.nih.gov/pubmed/31409002
http://dx.doi.org/10.3390/cancers11081156
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author Lin, Lehang
Lin, De-Chen
author_facet Lin, Lehang
Lin, De-Chen
author_sort Lin, Lehang
collection PubMed
description Esophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy, with hitherto dismal clinical outcome. Genomic analyses of patient samples reveal a complex heterogeneous landscape for ESCC, which presents in both intertumor and intratumor forms, manifests at both genomic and epigenomic levels, and contributes significantly to tumor evolution, drug resistance, and metastasis. Here, we review the important molecular characteristics underlying ESCC heterogeneity, with an emphasis on genomic aberrations and their functional contribution to cancer evolutionary trajectories. We further discuss how novel experimental tools, including single-cell sequencing and three-dimensional organoids, may advance our understanding of tumor heterogeneity. Lastly, we suggest that deciphering the mechanisms governing tumor heterogeneity holds the potential to developing precision therapeutics for ESCC patients.
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spelling pubmed-67216242019-09-10 Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma Lin, Lehang Lin, De-Chen Cancers (Basel) Review Esophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy, with hitherto dismal clinical outcome. Genomic analyses of patient samples reveal a complex heterogeneous landscape for ESCC, which presents in both intertumor and intratumor forms, manifests at both genomic and epigenomic levels, and contributes significantly to tumor evolution, drug resistance, and metastasis. Here, we review the important molecular characteristics underlying ESCC heterogeneity, with an emphasis on genomic aberrations and their functional contribution to cancer evolutionary trajectories. We further discuss how novel experimental tools, including single-cell sequencing and three-dimensional organoids, may advance our understanding of tumor heterogeneity. Lastly, we suggest that deciphering the mechanisms governing tumor heterogeneity holds the potential to developing precision therapeutics for ESCC patients. MDPI 2019-08-12 /pmc/articles/PMC6721624/ /pubmed/31409002 http://dx.doi.org/10.3390/cancers11081156 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Lehang
Lin, De-Chen
Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma
title Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma
title_full Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma
title_fullStr Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma
title_full_unstemmed Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma
title_short Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma
title_sort biological significance of tumor heterogeneity in esophageal squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721624/
https://www.ncbi.nlm.nih.gov/pubmed/31409002
http://dx.doi.org/10.3390/cancers11081156
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