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The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

Colorectal cancer (CRC) results from a transformation of colonic epithelial cells into adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of the surrounding stromal tumour microenvironment. Epithelial-specific epigenetic variations escorting this process include...

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Autores principales: Amirkhah, Raheleh, Naderi-Meshkin, Hojjat, Shah, Jaynish S., Dunne, Philip D., Schmitz, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721676/
https://www.ncbi.nlm.nih.gov/pubmed/31430887
http://dx.doi.org/10.3390/cells8080929
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author Amirkhah, Raheleh
Naderi-Meshkin, Hojjat
Shah, Jaynish S.
Dunne, Philip D.
Schmitz, Ulf
author_facet Amirkhah, Raheleh
Naderi-Meshkin, Hojjat
Shah, Jaynish S.
Dunne, Philip D.
Schmitz, Ulf
author_sort Amirkhah, Raheleh
collection PubMed
description Colorectal cancer (CRC) results from a transformation of colonic epithelial cells into adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of the surrounding stromal tumour microenvironment. Epithelial-specific epigenetic variations escorting this process include chromatin remodelling, histone modifications and aberrant DNA methylation, which influence gene expression, alternative splicing and function of non-coding RNA. In this review, we first highlight epigenetic modulators, modifiers and mediators in CRC, then we elaborate on causes and consequences of epigenetic alterations in CRC pathogenesis alongside an appraisal of the complex feedback mechanisms realized through alternative splicing and non-coding RNA regulation. An emphasis in our review is put on how this intricate network of epigenetic and post-transcriptional gene regulation evolves during the initiation, progression and metastasis formation in CRC.
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spelling pubmed-67216762019-09-10 The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer Amirkhah, Raheleh Naderi-Meshkin, Hojjat Shah, Jaynish S. Dunne, Philip D. Schmitz, Ulf Cells Review Colorectal cancer (CRC) results from a transformation of colonic epithelial cells into adenocarcinoma cells due to genetic and epigenetic instabilities, alongside remodelling of the surrounding stromal tumour microenvironment. Epithelial-specific epigenetic variations escorting this process include chromatin remodelling, histone modifications and aberrant DNA methylation, which influence gene expression, alternative splicing and function of non-coding RNA. In this review, we first highlight epigenetic modulators, modifiers and mediators in CRC, then we elaborate on causes and consequences of epigenetic alterations in CRC pathogenesis alongside an appraisal of the complex feedback mechanisms realized through alternative splicing and non-coding RNA regulation. An emphasis in our review is put on how this intricate network of epigenetic and post-transcriptional gene regulation evolves during the initiation, progression and metastasis formation in CRC. MDPI 2019-08-19 /pmc/articles/PMC6721676/ /pubmed/31430887 http://dx.doi.org/10.3390/cells8080929 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Amirkhah, Raheleh
Naderi-Meshkin, Hojjat
Shah, Jaynish S.
Dunne, Philip D.
Schmitz, Ulf
The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer
title The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer
title_full The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer
title_fullStr The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer
title_full_unstemmed The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer
title_short The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer
title_sort intricate interplay between epigenetic events, alternative splicing and noncoding rna deregulation in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721676/
https://www.ncbi.nlm.nih.gov/pubmed/31430887
http://dx.doi.org/10.3390/cells8080929
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