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Keeping the Centromere under Control: A Promising Role for DNA Methylation
In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity. Centromeres play an essential task in this process; they are special sites on chromosomes where kinetochores form on repetitive D...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721688/ https://www.ncbi.nlm.nih.gov/pubmed/31426433 http://dx.doi.org/10.3390/cells8080912 |
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author | Scelfo, Andrea Fachinetti, Daniele |
author_facet | Scelfo, Andrea Fachinetti, Daniele |
author_sort | Scelfo, Andrea |
collection | PubMed |
description | In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity. Centromeres play an essential task in this process; they are special sites on chromosomes where kinetochores form on repetitive DNA sequences to enable accurate chromosome segregation. Recent evidence suggests that centromeric DNA sequences, and epigenetic regulation of centromeres, have important roles in centromere physiology. In particular, DNA methylation is abundant at the centromere, and aberrant DNA methylation, observed in certain tumors, has been correlated to aneuploidy and genomic instability. In this review, we evaluate past and current insights on the relationship between centromere function and the DNA methylation pattern of its underlying sequences. |
format | Online Article Text |
id | pubmed-6721688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67216882019-09-10 Keeping the Centromere under Control: A Promising Role for DNA Methylation Scelfo, Andrea Fachinetti, Daniele Cells Review In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity. Centromeres play an essential task in this process; they are special sites on chromosomes where kinetochores form on repetitive DNA sequences to enable accurate chromosome segregation. Recent evidence suggests that centromeric DNA sequences, and epigenetic regulation of centromeres, have important roles in centromere physiology. In particular, DNA methylation is abundant at the centromere, and aberrant DNA methylation, observed in certain tumors, has been correlated to aneuploidy and genomic instability. In this review, we evaluate past and current insights on the relationship between centromere function and the DNA methylation pattern of its underlying sequences. MDPI 2019-08-16 /pmc/articles/PMC6721688/ /pubmed/31426433 http://dx.doi.org/10.3390/cells8080912 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Scelfo, Andrea Fachinetti, Daniele Keeping the Centromere under Control: A Promising Role for DNA Methylation |
title | Keeping the Centromere under Control: A Promising Role for DNA Methylation |
title_full | Keeping the Centromere under Control: A Promising Role for DNA Methylation |
title_fullStr | Keeping the Centromere under Control: A Promising Role for DNA Methylation |
title_full_unstemmed | Keeping the Centromere under Control: A Promising Role for DNA Methylation |
title_short | Keeping the Centromere under Control: A Promising Role for DNA Methylation |
title_sort | keeping the centromere under control: a promising role for dna methylation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721688/ https://www.ncbi.nlm.nih.gov/pubmed/31426433 http://dx.doi.org/10.3390/cells8080912 |
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