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Keeping the Centromere under Control: A Promising Role for DNA Methylation

In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity. Centromeres play an essential task in this process; they are special sites on chromosomes where kinetochores form on repetitive D...

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Detalles Bibliográficos
Autores principales: Scelfo, Andrea, Fachinetti, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721688/
https://www.ncbi.nlm.nih.gov/pubmed/31426433
http://dx.doi.org/10.3390/cells8080912
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author Scelfo, Andrea
Fachinetti, Daniele
author_facet Scelfo, Andrea
Fachinetti, Daniele
author_sort Scelfo, Andrea
collection PubMed
description In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity. Centromeres play an essential task in this process; they are special sites on chromosomes where kinetochores form on repetitive DNA sequences to enable accurate chromosome segregation. Recent evidence suggests that centromeric DNA sequences, and epigenetic regulation of centromeres, have important roles in centromere physiology. In particular, DNA methylation is abundant at the centromere, and aberrant DNA methylation, observed in certain tumors, has been correlated to aneuploidy and genomic instability. In this review, we evaluate past and current insights on the relationship between centromere function and the DNA methylation pattern of its underlying sequences.
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spelling pubmed-67216882019-09-10 Keeping the Centromere under Control: A Promising Role for DNA Methylation Scelfo, Andrea Fachinetti, Daniele Cells Review In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity. Centromeres play an essential task in this process; they are special sites on chromosomes where kinetochores form on repetitive DNA sequences to enable accurate chromosome segregation. Recent evidence suggests that centromeric DNA sequences, and epigenetic regulation of centromeres, have important roles in centromere physiology. In particular, DNA methylation is abundant at the centromere, and aberrant DNA methylation, observed in certain tumors, has been correlated to aneuploidy and genomic instability. In this review, we evaluate past and current insights on the relationship between centromere function and the DNA methylation pattern of its underlying sequences. MDPI 2019-08-16 /pmc/articles/PMC6721688/ /pubmed/31426433 http://dx.doi.org/10.3390/cells8080912 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Scelfo, Andrea
Fachinetti, Daniele
Keeping the Centromere under Control: A Promising Role for DNA Methylation
title Keeping the Centromere under Control: A Promising Role for DNA Methylation
title_full Keeping the Centromere under Control: A Promising Role for DNA Methylation
title_fullStr Keeping the Centromere under Control: A Promising Role for DNA Methylation
title_full_unstemmed Keeping the Centromere under Control: A Promising Role for DNA Methylation
title_short Keeping the Centromere under Control: A Promising Role for DNA Methylation
title_sort keeping the centromere under control: a promising role for dna methylation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721688/
https://www.ncbi.nlm.nih.gov/pubmed/31426433
http://dx.doi.org/10.3390/cells8080912
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