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Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine

During foetal life, the liver plays the important roles of connection and transient hematopoietic function. Foetal liver cells develop in an environment called a hematopoietic stem cell niche composed of several cell types, where stem cells can proliferate and give rise to mature blood cells. Embryo...

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Autores principales: Giancotti, Antonella, Monti, Marco, Nevi, Lorenzo, Safarikia, Samira, D’Ambrosio, Valentina, Brunelli, Roberto, Pajno, Cristina, Corno, Sara, Di Donato, Violante, Musella, Angela, Chiappetta, Michele Francesco, Bosco, Daniela, Benedetti Panici, Pierluigi, Alvaro, Domenico, Cardinale, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721721/
https://www.ncbi.nlm.nih.gov/pubmed/31426422
http://dx.doi.org/10.3390/cells8080914
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author Giancotti, Antonella
Monti, Marco
Nevi, Lorenzo
Safarikia, Samira
D’Ambrosio, Valentina
Brunelli, Roberto
Pajno, Cristina
Corno, Sara
Di Donato, Violante
Musella, Angela
Chiappetta, Michele Francesco
Bosco, Daniela
Benedetti Panici, Pierluigi
Alvaro, Domenico
Cardinale, Vincenzo
author_facet Giancotti, Antonella
Monti, Marco
Nevi, Lorenzo
Safarikia, Samira
D’Ambrosio, Valentina
Brunelli, Roberto
Pajno, Cristina
Corno, Sara
Di Donato, Violante
Musella, Angela
Chiappetta, Michele Francesco
Bosco, Daniela
Benedetti Panici, Pierluigi
Alvaro, Domenico
Cardinale, Vincenzo
author_sort Giancotti, Antonella
collection PubMed
description During foetal life, the liver plays the important roles of connection and transient hematopoietic function. Foetal liver cells develop in an environment called a hematopoietic stem cell niche composed of several cell types, where stem cells can proliferate and give rise to mature blood cells. Embryologically, at about the third week of gestation, the liver appears, and it grows rapidly from the fifth to 10th week under WNT/β-Catenin signaling pathway stimulation, which induces hepatic progenitor cells proliferation and differentiation into hepatocytes. Development of new strategies and identification of new cell sources should represent the main aim in liver regenerative medicine and cell therapy. Cells isolated from organs with endodermal origin, like the liver, bile ducts, and pancreas, could be preferable cell sources. Furthermore, stem cells isolated from these organs could be more susceptible to differentiate into mature liver cells after transplantation with respect to stem cells isolated from organs or tissues with a different embryological origin. The foetal liver possesses unique features given the co-existence of cells having endodermal and mesenchymal origin, and it could be highly available source candidate for regenerative medicine in both the liver and pancreas. Taking into account these advantages, the foetal liver can be the highest potential and available cell source for cell therapy regarding liver diseases and diabetes.
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spelling pubmed-67217212019-09-10 Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine Giancotti, Antonella Monti, Marco Nevi, Lorenzo Safarikia, Samira D’Ambrosio, Valentina Brunelli, Roberto Pajno, Cristina Corno, Sara Di Donato, Violante Musella, Angela Chiappetta, Michele Francesco Bosco, Daniela Benedetti Panici, Pierluigi Alvaro, Domenico Cardinale, Vincenzo Cells Review During foetal life, the liver plays the important roles of connection and transient hematopoietic function. Foetal liver cells develop in an environment called a hematopoietic stem cell niche composed of several cell types, where stem cells can proliferate and give rise to mature blood cells. Embryologically, at about the third week of gestation, the liver appears, and it grows rapidly from the fifth to 10th week under WNT/β-Catenin signaling pathway stimulation, which induces hepatic progenitor cells proliferation and differentiation into hepatocytes. Development of new strategies and identification of new cell sources should represent the main aim in liver regenerative medicine and cell therapy. Cells isolated from organs with endodermal origin, like the liver, bile ducts, and pancreas, could be preferable cell sources. Furthermore, stem cells isolated from these organs could be more susceptible to differentiate into mature liver cells after transplantation with respect to stem cells isolated from organs or tissues with a different embryological origin. The foetal liver possesses unique features given the co-existence of cells having endodermal and mesenchymal origin, and it could be highly available source candidate for regenerative medicine in both the liver and pancreas. Taking into account these advantages, the foetal liver can be the highest potential and available cell source for cell therapy regarding liver diseases and diabetes. MDPI 2019-08-16 /pmc/articles/PMC6721721/ /pubmed/31426422 http://dx.doi.org/10.3390/cells8080914 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giancotti, Antonella
Monti, Marco
Nevi, Lorenzo
Safarikia, Samira
D’Ambrosio, Valentina
Brunelli, Roberto
Pajno, Cristina
Corno, Sara
Di Donato, Violante
Musella, Angela
Chiappetta, Michele Francesco
Bosco, Daniela
Benedetti Panici, Pierluigi
Alvaro, Domenico
Cardinale, Vincenzo
Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
title Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
title_full Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
title_fullStr Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
title_full_unstemmed Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
title_short Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
title_sort functions and the emerging role of the foetal liver into regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721721/
https://www.ncbi.nlm.nih.gov/pubmed/31426422
http://dx.doi.org/10.3390/cells8080914
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