Pathogenic and Therapeutic Relevance of JAK/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent

Four Janus kinases (JAKs) (JAK1, JAK2, JAK3, TYK2) and seven signal transducers and activators of transcription (STATs) (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6) mediate the signal transduction of more than 50 cytokines and growth factors in many different cell types. Located intracellular...

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Detalles Bibliográficos
Autores principales: Alunno, Alessia, Padjen, Ivan, Fanouriakis, Antonis, Boumpas, Dimitrios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721755/
https://www.ncbi.nlm.nih.gov/pubmed/31443172
http://dx.doi.org/10.3390/cells8080898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721755/
https://www.ncbi.nlm.nih.gov/pubmed/31443172
http://dx.doi.org/10.3390/cells8080898

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