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Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disease, characterized by the presence of diverse autoantibodies and chronic inflammation. There are multiple factors involved in lupus pathogenesis, including genetic/epigenetic predisposition, sexual hormone imbalance, envir...

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Autores principales: Tsai, Chang-Youh, Shen, Chieh-Yu, Liao, Hsien-Tzung, Li, Ko-Jen, Lee, Hui-Ting, Lu, Cheng-Shiun, Wu, Cheng-Han, Kuo, Yu-Min, Hsieh, Song-Chou, Yu, Chia-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721773/
https://www.ncbi.nlm.nih.gov/pubmed/31395799
http://dx.doi.org/10.3390/ijms20163878
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author Tsai, Chang-Youh
Shen, Chieh-Yu
Liao, Hsien-Tzung
Li, Ko-Jen
Lee, Hui-Ting
Lu, Cheng-Shiun
Wu, Cheng-Han
Kuo, Yu-Min
Hsieh, Song-Chou
Yu, Chia-Li
author_facet Tsai, Chang-Youh
Shen, Chieh-Yu
Liao, Hsien-Tzung
Li, Ko-Jen
Lee, Hui-Ting
Lu, Cheng-Shiun
Wu, Cheng-Han
Kuo, Yu-Min
Hsieh, Song-Chou
Yu, Chia-Li
author_sort Tsai, Chang-Youh
collection PubMed
description Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disease, characterized by the presence of diverse autoantibodies and chronic inflammation. There are multiple factors involved in lupus pathogenesis, including genetic/epigenetic predisposition, sexual hormone imbalance, environmental stimulants, mental/psychological stresses, and undefined events. Recently, many authors noted that “inflammaging”, consisting of immunosenescence and inflammation, is a common feature in aging people and patients with SLE. It is conceivable that chronic oxidative stresses originating from mitochondrial dysfunction, defective bioenergetics, abnormal immunometabolism, and premature telomere erosion may accelerate immune cell senescence in patients with SLE. The mitochondrial dysfunctions in SLE have been extensively investigated in recent years. The molecular basis of normoglycemic metabolic syndrome has been found to be relevant to the production of advanced glycosylated and nitrosative end products. Besides, immunosenescence, autoimmunity, endothelial cell damage, and decreased tissue regeneration could be the results of premature telomere erosion in patients with SLE. Herein, the molecular and cellular bases of inflammaging and cardiovascular complications in SLE patients will be extensively reviewed from the aspects of mitochondrial dysfunctions, abnormal bioenergetics/immunometabolism, and telomere/telomerase disequilibrium.
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spelling pubmed-67217732019-09-10 Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus Tsai, Chang-Youh Shen, Chieh-Yu Liao, Hsien-Tzung Li, Ko-Jen Lee, Hui-Ting Lu, Cheng-Shiun Wu, Cheng-Han Kuo, Yu-Min Hsieh, Song-Chou Yu, Chia-Li Int J Mol Sci Review Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disease, characterized by the presence of diverse autoantibodies and chronic inflammation. There are multiple factors involved in lupus pathogenesis, including genetic/epigenetic predisposition, sexual hormone imbalance, environmental stimulants, mental/psychological stresses, and undefined events. Recently, many authors noted that “inflammaging”, consisting of immunosenescence and inflammation, is a common feature in aging people and patients with SLE. It is conceivable that chronic oxidative stresses originating from mitochondrial dysfunction, defective bioenergetics, abnormal immunometabolism, and premature telomere erosion may accelerate immune cell senescence in patients with SLE. The mitochondrial dysfunctions in SLE have been extensively investigated in recent years. The molecular basis of normoglycemic metabolic syndrome has been found to be relevant to the production of advanced glycosylated and nitrosative end products. Besides, immunosenescence, autoimmunity, endothelial cell damage, and decreased tissue regeneration could be the results of premature telomere erosion in patients with SLE. Herein, the molecular and cellular bases of inflammaging and cardiovascular complications in SLE patients will be extensively reviewed from the aspects of mitochondrial dysfunctions, abnormal bioenergetics/immunometabolism, and telomere/telomerase disequilibrium. MDPI 2019-08-09 /pmc/articles/PMC6721773/ /pubmed/31395799 http://dx.doi.org/10.3390/ijms20163878 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tsai, Chang-Youh
Shen, Chieh-Yu
Liao, Hsien-Tzung
Li, Ko-Jen
Lee, Hui-Ting
Lu, Cheng-Shiun
Wu, Cheng-Han
Kuo, Yu-Min
Hsieh, Song-Chou
Yu, Chia-Li
Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus
title Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus
title_full Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus
title_fullStr Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus
title_full_unstemmed Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus
title_short Molecular and Cellular Bases of Immunosenescence, Inflammation, and Cardiovascular Complications Mimicking “Inflammaging” in Patients with Systemic Lupus Erythematosus
title_sort molecular and cellular bases of immunosenescence, inflammation, and cardiovascular complications mimicking “inflammaging” in patients with systemic lupus erythematosus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721773/
https://www.ncbi.nlm.nih.gov/pubmed/31395799
http://dx.doi.org/10.3390/ijms20163878
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