Two New Flavonoids from the Nuts of Areca catechu

Two new flavonoids, calquiquelignan M (1), calquiquelignan N (2), along with nine known compounds (3–11), were isolated from the nuts of Areca catechu (Palmae). The new structures, including absolute configurations, were established by a combination of spectroscopic data and electronic circular dich...

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Detalles Bibliográficos
Autores principales: Yuan, Mengfei, Ao, Yunlin, Yao, Nan, Xie, Jing, Zhang, Dongmei, Zhang, Jian, Zhang, Xiaoqi, Ye, Wencai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721780/
https://www.ncbi.nlm.nih.gov/pubmed/31394749
http://dx.doi.org/10.3390/molecules24162862
Descripción
Sumario:Two new flavonoids, calquiquelignan M (1), calquiquelignan N (2), along with nine known compounds (3–11), were isolated from the nuts of Areca catechu (Palmae). The new structures, including absolute configurations, were established by a combination of spectroscopic data and electronic circular dichroism (ECD) calculation. The known compounds were identified by comparing their spectroscopic data with reported in the literature. The flavonoids compounds (1–8) were evaluated for their cytotoxicity activities against three human cancer cell lines. Compounds 1 and 2 exhibited a moderate cytotoxic activity against HepG2 cell lines with IC(50) values of 49.8 and 53.6 μM, respectively.

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