Two New Flavonoids from the Nuts of Areca catechu

Two new flavonoids, calquiquelignan M (1), calquiquelignan N (2), along with nine known compounds (3–11), were isolated from the nuts of Areca catechu (Palmae). The new structures, including absolute configurations, were established by a combination of spectroscopic data and electronic circular dich...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Mengfei, Ao, Yunlin, Yao, Nan, Xie, Jing, Zhang, Dongmei, Zhang, Jian, Zhang, Xiaoqi, Ye, Wencai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721780/
https://www.ncbi.nlm.nih.gov/pubmed/31394749
http://dx.doi.org/10.3390/molecules24162862
_version_ 1783448419040231424
author Yuan, Mengfei
Ao, Yunlin
Yao, Nan
Xie, Jing
Zhang, Dongmei
Zhang, Jian
Zhang, Xiaoqi
Ye, Wencai
author_facet Yuan, Mengfei
Ao, Yunlin
Yao, Nan
Xie, Jing
Zhang, Dongmei
Zhang, Jian
Zhang, Xiaoqi
Ye, Wencai
author_sort Yuan, Mengfei
collection PubMed
description Two new flavonoids, calquiquelignan M (1), calquiquelignan N (2), along with nine known compounds (3–11), were isolated from the nuts of Areca catechu (Palmae). The new structures, including absolute configurations, were established by a combination of spectroscopic data and electronic circular dichroism (ECD) calculation. The known compounds were identified by comparing their spectroscopic data with reported in the literature. The flavonoids compounds (1–8) were evaluated for their cytotoxicity activities against three human cancer cell lines. Compounds 1 and 2 exhibited a moderate cytotoxic activity against HepG2 cell lines with IC(50) values of 49.8 and 53.6 μM, respectively.
format Online
Article
Text
id pubmed-6721780
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67217802019-09-10 Two New Flavonoids from the Nuts of Areca catechu Yuan, Mengfei Ao, Yunlin Yao, Nan Xie, Jing Zhang, Dongmei Zhang, Jian Zhang, Xiaoqi Ye, Wencai Molecules Article Two new flavonoids, calquiquelignan M (1), calquiquelignan N (2), along with nine known compounds (3–11), were isolated from the nuts of Areca catechu (Palmae). The new structures, including absolute configurations, were established by a combination of spectroscopic data and electronic circular dichroism (ECD) calculation. The known compounds were identified by comparing their spectroscopic data with reported in the literature. The flavonoids compounds (1–8) were evaluated for their cytotoxicity activities against three human cancer cell lines. Compounds 1 and 2 exhibited a moderate cytotoxic activity against HepG2 cell lines with IC(50) values of 49.8 and 53.6 μM, respectively. MDPI 2019-08-07 /pmc/articles/PMC6721780/ /pubmed/31394749 http://dx.doi.org/10.3390/molecules24162862 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yuan, Mengfei
Ao, Yunlin
Yao, Nan
Xie, Jing
Zhang, Dongmei
Zhang, Jian
Zhang, Xiaoqi
Ye, Wencai
Two New Flavonoids from the Nuts of Areca catechu
title Two New Flavonoids from the Nuts of Areca catechu
title_full Two New Flavonoids from the Nuts of Areca catechu
title_fullStr Two New Flavonoids from the Nuts of Areca catechu
title_full_unstemmed Two New Flavonoids from the Nuts of Areca catechu
title_short Two New Flavonoids from the Nuts of Areca catechu
title_sort two new flavonoids from the nuts of areca catechu
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721780/
https://www.ncbi.nlm.nih.gov/pubmed/31394749
http://dx.doi.org/10.3390/molecules24162862
work_keys_str_mv AT yuanmengfei twonewflavonoidsfromthenutsofarecacatechu
AT aoyunlin twonewflavonoidsfromthenutsofarecacatechu
AT yaonan twonewflavonoidsfromthenutsofarecacatechu
AT xiejing twonewflavonoidsfromthenutsofarecacatechu
AT zhangdongmei twonewflavonoidsfromthenutsofarecacatechu
AT zhangjian twonewflavonoidsfromthenutsofarecacatechu
AT zhangxiaoqi twonewflavonoidsfromthenutsofarecacatechu
AT yewencai twonewflavonoidsfromthenutsofarecacatechu

Ejemplares similares