An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

Removing or preventing the formation of [Formula: see text]-synuclein aggregates is a plausible strategy against Parkinson’s disease. To this end, we have engineered the [Formula: see text]-wrapin AS69 to bind monomeric [Formula: see text]-synuclein with high affinity. In cultured cells, AS69 reduce...

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Detalles Bibliográficos
Autores principales: Agerschou, Emil Dandanell, Flagmeier, Patrick, Saridaki, Theodora, Galvagnion, Céline, Komnig, Daniel, Heid, Laetitia, Prasad, Vibha, Shaykhalishahi, Hamed, Willbold, Dieter, Dobson, Christopher M, Voigt, Aaron, Falkenburger, Bjoern, Hoyer, Wolfgang, Buell, Alexander K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721797/
https://www.ncbi.nlm.nih.gov/pubmed/31389332
http://dx.doi.org/10.7554/eLife.46112

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