Novel Antibody-Drug Conjugate with Anti-CD26 Humanized Monoclonal Antibody and Transcription Factor IIH (TFIIH) Inhibitor, Triptolide, Inhibits Tumor Growth via Impairing mRNA Synthesis

Here, we report a novel antibody drug conjugate (ADC) with the humanized anti-CD26 monoclonal antibody YS110 and triptolide (TR-1). YS110 has an inhibitory activity against the CD26-positive tumor growth via the immunological and direct pathway, such as intra-nuclear transportation of CD26 and YS110...

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Detalles Bibliográficos
Autores principales: Hayashi, Mutsumi, Madokoro, Hiroko, Yamada, Koji, Nishida, Hiroko, Morimoto, Chikao, Sakamoto, Michiie, Yanagawa, Hiroshi, Yamada, Taketo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721810/
https://www.ncbi.nlm.nih.gov/pubmed/31398954
http://dx.doi.org/10.3390/cancers11081138

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