TRAIL Induces Nuclear Translocation and Chromatin Localization of TRAIL Death Receptors

Binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to the plasma membrane TRAIL-R1/-R2 selectively kills tumor cells. This discovery led to evaluation of TRAIL-R1/-R2 as targets for anti-cancer therapy, yet the corresponding clinical trials were disappointing. Meanwhile, it e...

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Detalles Bibliográficos
Autores principales: Mert, Ufuk, Adawy, Alshaimaa, Scharff, Elisabeth, Teichmann, Pierre, Willms, Anna, Haselmann, Verena, Colmorgen, Cynthia, Lemke, Johannes, von Karstedt, Silvia, Fritsch, Jürgen, Trauzold, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721811/
https://www.ncbi.nlm.nih.gov/pubmed/31416165
http://dx.doi.org/10.3390/cancers11081167

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