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MicroRNAs in Obesity and Related Metabolic Disorders

Metabolic disorders are characterized by the inability to properly use and/or store energy. The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through a complex interplay between genetics and epigenetics predisposition, environment and nutrition. Therefore, understa...

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Autores principales: Landrier, Jean-François, Derghal, Adel, Mounien, Lourdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721826/
https://www.ncbi.nlm.nih.gov/pubmed/31404962
http://dx.doi.org/10.3390/cells8080859
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author Landrier, Jean-François
Derghal, Adel
Mounien, Lourdes
author_facet Landrier, Jean-François
Derghal, Adel
Mounien, Lourdes
author_sort Landrier, Jean-François
collection PubMed
description Metabolic disorders are characterized by the inability to properly use and/or store energy. The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through a complex interplay between genetics and epigenetics predisposition, environment and nutrition. Therefore, understanding the molecular mechanisms for the onset of metabolic disease will provide new insights for prevention and treatment. There is growing concern about the dysregulation of micro-RNAs (miRNAs) in metabolic diseases. MiRNAs are short non-coding RNA molecules that post-transcriptionally repress the expression of genes by binding to untranslated regions and coding sequences of the target mRNAs. This review aims to provide recent data about the potential involvement of miRNAs in metabolic diseases, particularly obesity and type 2 diabetes.
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spelling pubmed-67218262019-09-10 MicroRNAs in Obesity and Related Metabolic Disorders Landrier, Jean-François Derghal, Adel Mounien, Lourdes Cells Review Metabolic disorders are characterized by the inability to properly use and/or store energy. The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through a complex interplay between genetics and epigenetics predisposition, environment and nutrition. Therefore, understanding the molecular mechanisms for the onset of metabolic disease will provide new insights for prevention and treatment. There is growing concern about the dysregulation of micro-RNAs (miRNAs) in metabolic diseases. MiRNAs are short non-coding RNA molecules that post-transcriptionally repress the expression of genes by binding to untranslated regions and coding sequences of the target mRNAs. This review aims to provide recent data about the potential involvement of miRNAs in metabolic diseases, particularly obesity and type 2 diabetes. MDPI 2019-08-09 /pmc/articles/PMC6721826/ /pubmed/31404962 http://dx.doi.org/10.3390/cells8080859 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Landrier, Jean-François
Derghal, Adel
Mounien, Lourdes
MicroRNAs in Obesity and Related Metabolic Disorders
title MicroRNAs in Obesity and Related Metabolic Disorders
title_full MicroRNAs in Obesity and Related Metabolic Disorders
title_fullStr MicroRNAs in Obesity and Related Metabolic Disorders
title_full_unstemmed MicroRNAs in Obesity and Related Metabolic Disorders
title_short MicroRNAs in Obesity and Related Metabolic Disorders
title_sort micrornas in obesity and related metabolic disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721826/
https://www.ncbi.nlm.nih.gov/pubmed/31404962
http://dx.doi.org/10.3390/cells8080859
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