HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients

Non-small-cell lung cancer (NSCLC) is the most common non-AIDS defining cancer in patients infected with HIV and has the highest mortality rate among all cancers in this patient population. Treatment of NSCLC in HIV-positive patients is similar to that in HIV-negative patients, but less is known abo...

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Autores principales: Pichardo, Rayli, Go, Rafael Francisco, Qu, Lang, Hussein, Lily, Gupta, Shweta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
HIV/AIDS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721879/
https://www.ncbi.nlm.nih.gov/pubmed/31523585
http://dx.doi.org/10.7759/cureus.5466
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author Pichardo, Rayli
Go, Rafael Francisco
Qu, Lang
Hussein, Lily
Gupta, Shweta
author_facet Pichardo, Rayli
Go, Rafael Francisco
Qu, Lang
Hussein, Lily
Gupta, Shweta
author_sort Pichardo, Rayli
collection PubMed
description Non-small-cell lung cancer (NSCLC) is the most common non-AIDS defining cancer in patients infected with HIV and has the highest mortality rate among all cancers in this patient population. Treatment of NSCLC in HIV-positive patients is similar to that in HIV-negative patients, but less is known about the molecular characteristics of NSCLC in HIV-positive patients. This report describes two patients with HIV-associated NSCLC and rearrangements of the anaplastic lymphoma kinase (ALK) gene. The disease followed an indolent course in both patients.
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spelling pubmed-67218792019-09-13 HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients Pichardo, Rayli Go, Rafael Francisco Qu, Lang Hussein, Lily Gupta, Shweta Cureus HIV/AIDS Non-small-cell lung cancer (NSCLC) is the most common non-AIDS defining cancer in patients infected with HIV and has the highest mortality rate among all cancers in this patient population. Treatment of NSCLC in HIV-positive patients is similar to that in HIV-negative patients, but less is known about the molecular characteristics of NSCLC in HIV-positive patients. This report describes two patients with HIV-associated NSCLC and rearrangements of the anaplastic lymphoma kinase (ALK) gene. The disease followed an indolent course in both patients. Cureus 2019-08-22 /pmc/articles/PMC6721879/ /pubmed/31523585 http://dx.doi.org/10.7759/cureus.5466 Text en Copyright © 2019, Pichardo et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle HIV/AIDS
Pichardo, Rayli
Go, Rafael Francisco
Qu, Lang
Hussein, Lily
Gupta, Shweta
HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients
title HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients
title_full HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients
title_fullStr HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients
title_full_unstemmed HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients
title_short HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients
title_sort hiv-associated non-small-cell lung cancer with rearrangement of the anaplastic lymphoma kinase gene: a report of two patients
topic HIV/AIDS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721879/
https://www.ncbi.nlm.nih.gov/pubmed/31523585
http://dx.doi.org/10.7759/cureus.5466
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