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The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder

Excessive arousal has a role in the pathophysiology of major depressive disorder (MDD). Seltorexant (JNJ-42847922/MIN-202) is a selective antagonist of the human orexin-2 receptor (OX2R) that may normalize excessive arousal and thereby attenuate depressive symptoms. In this study, the effects of nig...

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Detalles Bibliográficos
Autores principales:	Recourt, Kasper, de Boer, Peter, Zuiker, Rob, Luthringer, Remy, Kent, Justine, van der Ark, Peter, Van Hove, Ilse, van Gerven, Joop, Jacobs, Gabriel, van Nueten, Luc, Drevets, Wayne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722075/ https://www.ncbi.nlm.nih.gov/pubmed/31481683 http://dx.doi.org/10.1038/s41398-019-0553-z

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