A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

Genome-wide CRISPR screening is a powerful tool to identify genes required under selective conditions. However, the inherent scale of genome-wide libraries can limit their application in experimental settings where cell numbers are restricted, such as in vivo infections or single cell analysis. The...

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Detalles Bibliográficos
Autores principales: Young, Joanna, Dominicus, Caia, Wagener, Jeanette, Butterworth, Simon, Ye, Xingda, Kelly, Gavin, Ordan, Merav, Saunders, Becky, Instrell, Rachael, Howell, Michael, Stewart, Aengus, Treeck, Moritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722137/
https://www.ncbi.nlm.nih.gov/pubmed/31481656
http://dx.doi.org/10.1038/s41467-019-11855-w

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