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Mathematical modeling of drug-induced receptor internalization in the HER2-positive SKBR3 breast cancer cell-line
About 20% of breast cancer tumors over-express the HER2 receptor. Trastuzumab, an approved drug to treat this type of breast cancer, is a monoclonal antibody directly binding at the HER2 receptor and ultimately inhibiting cancer cell growth. The goal of our study was to understand the early impact o...
Autores principales: | Fehling-Kaschek, Mirjam, Peckys, Diana B., Kaschek, Daniel, Timmer, Jens, Jonge, Niels de |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722142/ https://www.ncbi.nlm.nih.gov/pubmed/31481718 http://dx.doi.org/10.1038/s41598-019-49019-x |
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