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The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications
Deinococcus is an extremophilic microorganism found in a wide range of habitats, including hot springs, radiation-contaminated areas, Antarctic soils, deserts, etc., and shows some of the highest levels of resistance to ionizing radiation known in nature. The highly efficient radiation-protection me...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722170/ https://www.ncbi.nlm.nih.gov/pubmed/31482336 http://dx.doi.org/10.1186/s13568-019-0862-x |
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author | Jin, Mengmeng Xiao, Anqi Zhu, Liying Zhang, Zhidong Huang, He Jiang, Ling |
author_facet | Jin, Mengmeng Xiao, Anqi Zhu, Liying Zhang, Zhidong Huang, He Jiang, Ling |
author_sort | Jin, Mengmeng |
collection | PubMed |
description | Deinococcus is an extremophilic microorganism found in a wide range of habitats, including hot springs, radiation-contaminated areas, Antarctic soils, deserts, etc., and shows some of the highest levels of resistance to ionizing radiation known in nature. The highly efficient radiation-protection mechanisms of Deinococcus depend on a combination of passive and active defense mechanisms, including self-repair of DNA damage (homologous recombination, MMR, ER and ESDSA), efficient cellular damage clearance mechanisms (hydrolysis of damaged proteins, overexpression of repair proteins, etc.), and effective clearance of reactive oxygen species (ROS). Due to these mechanisms, Deinococcus cells are highly resistant to oxidation, radiation and desiccation, which makes them potential chassis cells for wide applications in many fields. This article summarizes the latest research on the radiation-resistance mechanisms of Deinococcus and prospects its biotechnological application potentials. |
format | Online Article Text |
id | pubmed-6722170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-67221702019-09-17 The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications Jin, Mengmeng Xiao, Anqi Zhu, Liying Zhang, Zhidong Huang, He Jiang, Ling AMB Express Mini-Review Deinococcus is an extremophilic microorganism found in a wide range of habitats, including hot springs, radiation-contaminated areas, Antarctic soils, deserts, etc., and shows some of the highest levels of resistance to ionizing radiation known in nature. The highly efficient radiation-protection mechanisms of Deinococcus depend on a combination of passive and active defense mechanisms, including self-repair of DNA damage (homologous recombination, MMR, ER and ESDSA), efficient cellular damage clearance mechanisms (hydrolysis of damaged proteins, overexpression of repair proteins, etc.), and effective clearance of reactive oxygen species (ROS). Due to these mechanisms, Deinococcus cells are highly resistant to oxidation, radiation and desiccation, which makes them potential chassis cells for wide applications in many fields. This article summarizes the latest research on the radiation-resistance mechanisms of Deinococcus and prospects its biotechnological application potentials. Springer Berlin Heidelberg 2019-09-03 /pmc/articles/PMC6722170/ /pubmed/31482336 http://dx.doi.org/10.1186/s13568-019-0862-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Mini-Review Jin, Mengmeng Xiao, Anqi Zhu, Liying Zhang, Zhidong Huang, He Jiang, Ling The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications |
title | The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications |
title_full | The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications |
title_fullStr | The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications |
title_full_unstemmed | The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications |
title_short | The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications |
title_sort | diversity and commonalities of the radiation-resistance mechanisms of deinococcus and its up-to-date applications |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722170/ https://www.ncbi.nlm.nih.gov/pubmed/31482336 http://dx.doi.org/10.1186/s13568-019-0862-x |
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