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The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications

Deinococcus is an extremophilic microorganism found in a wide range of habitats, including hot springs, radiation-contaminated areas, Antarctic soils, deserts, etc., and shows some of the highest levels of resistance to ionizing radiation known in nature. The highly efficient radiation-protection me...

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Autores principales: Jin, Mengmeng, Xiao, Anqi, Zhu, Liying, Zhang, Zhidong, Huang, He, Jiang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722170/
https://www.ncbi.nlm.nih.gov/pubmed/31482336
http://dx.doi.org/10.1186/s13568-019-0862-x
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author Jin, Mengmeng
Xiao, Anqi
Zhu, Liying
Zhang, Zhidong
Huang, He
Jiang, Ling
author_facet Jin, Mengmeng
Xiao, Anqi
Zhu, Liying
Zhang, Zhidong
Huang, He
Jiang, Ling
author_sort Jin, Mengmeng
collection PubMed
description Deinococcus is an extremophilic microorganism found in a wide range of habitats, including hot springs, radiation-contaminated areas, Antarctic soils, deserts, etc., and shows some of the highest levels of resistance to ionizing radiation known in nature. The highly efficient radiation-protection mechanisms of Deinococcus depend on a combination of passive and active defense mechanisms, including self-repair of DNA damage (homologous recombination, MMR, ER and ESDSA), efficient cellular damage clearance mechanisms (hydrolysis of damaged proteins, overexpression of repair proteins, etc.), and effective clearance of reactive oxygen species (ROS). Due to these mechanisms, Deinococcus cells are highly resistant to oxidation, radiation and desiccation, which makes them potential chassis cells for wide applications in many fields. This article summarizes the latest research on the radiation-resistance mechanisms of Deinococcus and prospects its biotechnological application potentials.
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spelling pubmed-67221702019-09-17 The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications Jin, Mengmeng Xiao, Anqi Zhu, Liying Zhang, Zhidong Huang, He Jiang, Ling AMB Express Mini-Review Deinococcus is an extremophilic microorganism found in a wide range of habitats, including hot springs, radiation-contaminated areas, Antarctic soils, deserts, etc., and shows some of the highest levels of resistance to ionizing radiation known in nature. The highly efficient radiation-protection mechanisms of Deinococcus depend on a combination of passive and active defense mechanisms, including self-repair of DNA damage (homologous recombination, MMR, ER and ESDSA), efficient cellular damage clearance mechanisms (hydrolysis of damaged proteins, overexpression of repair proteins, etc.), and effective clearance of reactive oxygen species (ROS). Due to these mechanisms, Deinococcus cells are highly resistant to oxidation, radiation and desiccation, which makes them potential chassis cells for wide applications in many fields. This article summarizes the latest research on the radiation-resistance mechanisms of Deinococcus and prospects its biotechnological application potentials. Springer Berlin Heidelberg 2019-09-03 /pmc/articles/PMC6722170/ /pubmed/31482336 http://dx.doi.org/10.1186/s13568-019-0862-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Mini-Review
Jin, Mengmeng
Xiao, Anqi
Zhu, Liying
Zhang, Zhidong
Huang, He
Jiang, Ling
The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications
title The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications
title_full The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications
title_fullStr The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications
title_full_unstemmed The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications
title_short The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications
title_sort diversity and commonalities of the radiation-resistance mechanisms of deinococcus and its up-to-date applications
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722170/
https://www.ncbi.nlm.nih.gov/pubmed/31482336
http://dx.doi.org/10.1186/s13568-019-0862-x
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