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Early life determinants induce sustainable changes in the gut microbiome of six-year-old children

While the association between early life determinants and the development of the gut microbiome composition in infancy has been widely investigated, a potential persistent influence of early life determinants on the gut microbial community after its stabilization at later childhood remains largely u...

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Autores principales: Gschwendtner, Silvia, Kang, Hyena, Thiering, Elisabeth, Kublik, Susanne, Fösel, Bärbel, Schulz, Holger, Krauss-Etschmann, Susanne, Heinrich, Joachim, Schöler, Anne, Schloter, Michael, Standl, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722248/
https://www.ncbi.nlm.nih.gov/pubmed/31481742
http://dx.doi.org/10.1038/s41598-019-49160-7
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author Gschwendtner, Silvia
Kang, Hyena
Thiering, Elisabeth
Kublik, Susanne
Fösel, Bärbel
Schulz, Holger
Krauss-Etschmann, Susanne
Heinrich, Joachim
Schöler, Anne
Schloter, Michael
Standl, Marie
author_facet Gschwendtner, Silvia
Kang, Hyena
Thiering, Elisabeth
Kublik, Susanne
Fösel, Bärbel
Schulz, Holger
Krauss-Etschmann, Susanne
Heinrich, Joachim
Schöler, Anne
Schloter, Michael
Standl, Marie
author_sort Gschwendtner, Silvia
collection PubMed
description While the association between early life determinants and the development of the gut microbiome composition in infancy has been widely investigated, a potential persistent influence of early life determinants on the gut microbial community after its stabilization at later childhood remains largely unknown. Therefore, we aimed to identify the association between several early life determinants and the gut microbiome composition in six-year-old children from the LISA birth cohort. A total number of 166 fecal samples were analyzed using 16S rRNA gene-based barcoding to assess bacterial diversity pattern. The bacterial profiles were investigated for their association with maternal smoking during pregnancy, mode of delivery, breastfeeding, antibiotic treatment between one and two years of age, gender and socioeconomic status (SES). While alpha and beta diversity of the infants’ gut microbiome remained unaffected, amplicon sequence variants (ASVs) annotated to Firmicutes and Actinobacteria responded to early life determinants, mostly to feeding practice and antibiotics use. ASVs associated to Bacteriodetes remained unaffected. Our findings indicate that early life determinants could have a long-term sustainable effect on the gut microflora of six-year-old children, however, associations with early life determinates are weaker than reported for infants.
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spelling pubmed-67222482019-09-18 Early life determinants induce sustainable changes in the gut microbiome of six-year-old children Gschwendtner, Silvia Kang, Hyena Thiering, Elisabeth Kublik, Susanne Fösel, Bärbel Schulz, Holger Krauss-Etschmann, Susanne Heinrich, Joachim Schöler, Anne Schloter, Michael Standl, Marie Sci Rep Article While the association between early life determinants and the development of the gut microbiome composition in infancy has been widely investigated, a potential persistent influence of early life determinants on the gut microbial community after its stabilization at later childhood remains largely unknown. Therefore, we aimed to identify the association between several early life determinants and the gut microbiome composition in six-year-old children from the LISA birth cohort. A total number of 166 fecal samples were analyzed using 16S rRNA gene-based barcoding to assess bacterial diversity pattern. The bacterial profiles were investigated for their association with maternal smoking during pregnancy, mode of delivery, breastfeeding, antibiotic treatment between one and two years of age, gender and socioeconomic status (SES). While alpha and beta diversity of the infants’ gut microbiome remained unaffected, amplicon sequence variants (ASVs) annotated to Firmicutes and Actinobacteria responded to early life determinants, mostly to feeding practice and antibiotics use. ASVs associated to Bacteriodetes remained unaffected. Our findings indicate that early life determinants could have a long-term sustainable effect on the gut microflora of six-year-old children, however, associations with early life determinates are weaker than reported for infants. Nature Publishing Group UK 2019-09-03 /pmc/articles/PMC6722248/ /pubmed/31481742 http://dx.doi.org/10.1038/s41598-019-49160-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Gschwendtner, Silvia
Kang, Hyena
Thiering, Elisabeth
Kublik, Susanne
Fösel, Bärbel
Schulz, Holger
Krauss-Etschmann, Susanne
Heinrich, Joachim
Schöler, Anne
Schloter, Michael
Standl, Marie
Early life determinants induce sustainable changes in the gut microbiome of six-year-old children
title Early life determinants induce sustainable changes in the gut microbiome of six-year-old children
title_full Early life determinants induce sustainable changes in the gut microbiome of six-year-old children
title_fullStr Early life determinants induce sustainable changes in the gut microbiome of six-year-old children
title_full_unstemmed Early life determinants induce sustainable changes in the gut microbiome of six-year-old children
title_short Early life determinants induce sustainable changes in the gut microbiome of six-year-old children
title_sort early life determinants induce sustainable changes in the gut microbiome of six-year-old children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722248/
https://www.ncbi.nlm.nih.gov/pubmed/31481742
http://dx.doi.org/10.1038/s41598-019-49160-7
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