VDR agonists down regulate PI3K/Akt/mTOR axis and trigger autophagy in Kaposi's sarcoma cells

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor (KSHV/vGPCR) is a key molecule in the pathogenesis of Kaposi's sarcoma. We have previously shown that 1α,25(OH)(2)D(3) or its less-calcemic analog TX 527 inhibits the proliferation of endothelial cells expressing vGPCR,...

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Detalles Bibliográficos
Autores principales: Suares, Alejandra, Tapia, Cinthya, González-Pardo, Verónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722267/
https://www.ncbi.nlm.nih.gov/pubmed/31497671
http://dx.doi.org/10.1016/j.heliyon.2019.e02367

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