Cargando…

Optimizing Modified mRNA In Vitro Synthesis Protocol for Heart Gene Therapy

Synthetic modified RNA (modRNA) is a novel vector for gene transfer to the heart and other organs. modRNA can mediate strong, transient protein expression with minimal induction of the innate immune response and risk for genome integration. modRNA is already being used in several human clinical tria...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hadas, Yoav, Sultana, Nishat, Youssef, Elias, Sharkar, Mohammad Tofael Kabir, Kaur, Keerat, Chepurko, Elena, Zangi, Lior
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722299/ https://www.ncbi.nlm.nih.gov/pubmed/31508439 http://dx.doi.org/10.1016/j.omtm.2019.07.006

Ejemplares similares

Optimization of 5′ Untranslated Region of Modified mRNA for Use in Cardiac or Hepatic Ischemic Injury
por: Sultana, Nishat, et al.
Publicado: (2020)

Therapeutic Delivery of Pip4k2c‐Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart
por: Magadum, Ajit, et al.
Publicado: (2021)

Modified mRNA as a Therapeutic Tool for the Heart
por: Kaur, Keerat, et al.
Publicado: (2020)

Ablation of a Single N-Glycosylation Site in Human FSTL 1 Induces Cardiomyocyte Proliferation and Cardiac Regeneration
por: Magadum, Ajit, et al.
Publicado: (2018)

Direct reprogramming induces vascular regeneration post muscle ischemic injury
por: Kaur, Keerat, et al.
Publicado: (2021)

mRNA-Based Protein Replacement Therapy for the Heart
por: Magadum, Ajit, et al.
Publicado: (2019)

Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery
por: Żak, Magdalena M., et al.
Publicado: (2023)

Lipid Nanoparticles for Organ-Specific mRNA Therapeutic Delivery
por: Żak, Magdalena M., et al.
Publicado: (2021)

Driving vascular endothelial cell fate of human multipotent Isl1(+) heart progenitors with VEGF modified mRNA
por: Lui, Kathy O, et al.
Publicado: (2013)

Synthesis of point-modified mRNA
por: Hertler, Jasmin, et al.
Publicado: (2022)

Modified mRNA Therapeutics for Heart Diseases
por: Magadum, Ajit
Publicado: (2022)

A study of calcaneal enthesophytes (spurs) in Indian population
por: Kullar, Jagdev Singh, et al.
Publicado: (2014)

Duration of postoperative analgesia with Nalbuphine vs Butorphanol as an adjunct to spinal anesthesia for lower limb orthopedic surgeries: A randomized double-blind active control trial
por: Kumari, Anita, et al.
Publicado: (2021)

Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration
por: Xia, Yu, et al.
Publicado: (2022)

Chimp optimization algorithm in multilevel image thresholding and image clustering
por: Eisham, Zubayer Kabir, et al.
Publicado: (2022)

Optimized conditions for successful transfection of human endothelial cells with in vitro synthesized and modified mRNA for induction of protein expression
por: Avci-Adali, Meltem, et al.
Publicado: (2014)

Comparison of intrathecal bupivacaine-fentanyl and bupivacaine-butorphanol combinations for joint replacement surgeries
por: Sharma, Aakriti, et al.
Publicado: (2022)

Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine
por: Gebre, Makda S., et al.
Publicado: (2021)

Evaluating the effectiveness of TENS for maternal satisfaction in laboring parturients – Comparison with epidural analgesia
por: Gupta, Ruchi, et al.
Publicado: (2020)

A Recombinant Collagen–mRNA Platform for Controllable Protein Synthesis
por: Sun, Liping, et al.
Publicado: (2015)

Effect of Fentanyl on Block Characteristics as Adjuvant to Intrathecal Bupivacaine for Lower Limb Surgeries
por: Abbi, Pooja, et al.
Publicado: (2020)

Predictive biophysical modeling and understanding of the dynamics of mRNA translation and its evolution
por: Zur, Hadas, et al.
Publicado: (2016)

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
por: Karikó, Katalin, et al.
Publicado: (2011)

Discharge readiness after minor gynaecological surgeries comparing dexmedetomidine and ketamine premedication in bispectral index (BIS) guided propofol-based anaesthesia
por: Kaur, Gaganjot, et al.
Publicado: (2021)

Pear Recognition in an Orchard from 3D Stereo Camera Datasets to Develop a Fruit Picking Mechanism Using Mask R-CNN
por: Pan, Siyu, et al.
Publicado: (2022)

Navigation of an Autonomous Spraying Robot for Orchard Operations Using LiDAR for Tree Trunk Detection
por: Jiang, Ailian, et al.
Publicado: (2023)

Pre-mRNA Splicing Is a Determinant of Nucleosome Organization
por: Keren-Shaul, Hadas, et al.
Publicado: (2013)

Pre-mRNA splicing is a determinant of nucleosome organization
por: Keren-Shaul, Hadas, et al.
Publicado: (2013)

Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics
por: Cheng, Mingrong, et al.
Publicado: (2014)

Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction
por: Shilo, Malka, et al.
Publicado: (2021)

Modified Optimism
Publicado: (1921)

Refinement of the OPLSAA Force-Field for Liquid Alcohols
por: Zangi, Ronen
Publicado: (2018)

Multimerizations, Aggregation, and Transfer Reactions of Small Numbers of Molecules
por: Zangi, Ronen
Publicado: (2023)

Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction
por: Katz, Michael G., et al.
Publicado: (2023)

Enhanced chimp optimization algorithm for high level synthesis of digital filters
por: Kaur, Mandeep, et al.
Publicado: (2022)

Length biases in single-cell RNA sequencing of pre-mRNA
por: Gorin, Gennady, et al.
Publicado: (2022)

Development of an Early Embryo Detection Methodology for Quail Eggs Using a Thermal Micro Camera and the YOLO Deep Learning Algorithm
por: Nakaguchi, Victor Massaki, et al.
Publicado: (2022)

Fast and Non-Destructive Quail Egg Freshness Assessment Using a Thermal Camera and Deep Learning-Based Air Cell Detection Algorithms for the Revalidation of the Expiration Date of Eggs
por: Nakaguchi, Victor Massaki, et al.
Publicado: (2022)

Detection of Tip-Burn Stress on Lettuce Grown in an Indoor Environment Using Deep Learning Algorithms
por: Hamidon, Munirah Hayati, et al.
Publicado: (2022)

Sooty Mold Detection on Citrus Tree Canopy Using Deep Learning Algorithms
por: Apacionado, Bryan Vivas, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cmbj0ejrr3ni9n92a673bokbcg