Now You See It, Now You Do Not: A Case of Infliximab-Induced Vanishing Bile Duct Syndrome

Infliximab is a commonly used antitumor necrosis factor alpha agent, especially in patients with inflammatory bowel disease. It has been associated with drug-induced liver injury including immunologic reactions, with rare cases of acute liver failure. We describe a patient with chronic cholestasis a...

Descripción completa

Detalles Bibliográficos
Autores principales: Shah, Parth, Larson, Brent, Wishingrad, Marc, Nissen, Nicholas, Björnsson, Einar, Sundaram, Vinay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722359/
https://www.ncbi.nlm.nih.gov/pubmed/31620531
http://dx.doi.org/10.14309/crj.0000000000000134
_version_ 1783448519269416960
author Shah, Parth
Larson, Brent
Wishingrad, Marc
Nissen, Nicholas
Björnsson, Einar
Sundaram, Vinay
author_facet Shah, Parth
Larson, Brent
Wishingrad, Marc
Nissen, Nicholas
Björnsson, Einar
Sundaram, Vinay
author_sort Shah, Parth
collection PubMed
description Infliximab is a commonly used antitumor necrosis factor alpha agent, especially in patients with inflammatory bowel disease. It has been associated with drug-induced liver injury including immunologic reactions, with rare cases of acute liver failure. We describe a patient with chronic cholestasis and loss of intrahepatic bile ducts after therapy with infliximab for refractory ulcerative colitis consistent with a diagnosis of vanishing bile duct syndrome. About 3 months after the initial infusion, the patient developed subfulminant liver failure and required liver transplantation.
format Online
Article
Text
id pubmed-6722359
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer
record_format MEDLINE/PubMed
spelling pubmed-67223592019-10-16 Now You See It, Now You Do Not: A Case of Infliximab-Induced Vanishing Bile Duct Syndrome Shah, Parth Larson, Brent Wishingrad, Marc Nissen, Nicholas Björnsson, Einar Sundaram, Vinay ACG Case Rep J Case Report Infliximab is a commonly used antitumor necrosis factor alpha agent, especially in patients with inflammatory bowel disease. It has been associated with drug-induced liver injury including immunologic reactions, with rare cases of acute liver failure. We describe a patient with chronic cholestasis and loss of intrahepatic bile ducts after therapy with infliximab for refractory ulcerative colitis consistent with a diagnosis of vanishing bile duct syndrome. About 3 months after the initial infusion, the patient developed subfulminant liver failure and required liver transplantation. Wolters Kluwer 2019-07-10 /pmc/articles/PMC6722359/ /pubmed/31620531 http://dx.doi.org/10.14309/crj.0000000000000134 Text en © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Shah, Parth
Larson, Brent
Wishingrad, Marc
Nissen, Nicholas
Björnsson, Einar
Sundaram, Vinay
Now You See It, Now You Do Not: A Case of Infliximab-Induced Vanishing Bile Duct Syndrome
title Now You See It, Now You Do Not: A Case of Infliximab-Induced Vanishing Bile Duct Syndrome
title_full Now You See It, Now You Do Not: A Case of Infliximab-Induced Vanishing Bile Duct Syndrome
title_fullStr Now You See It, Now You Do Not: A Case of Infliximab-Induced Vanishing Bile Duct Syndrome
title_full_unstemmed Now You See It, Now You Do Not: A Case of Infliximab-Induced Vanishing Bile Duct Syndrome
title_short Now You See It, Now You Do Not: A Case of Infliximab-Induced Vanishing Bile Duct Syndrome
title_sort now you see it, now you do not: a case of infliximab-induced vanishing bile duct syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722359/
https://www.ncbi.nlm.nih.gov/pubmed/31620531
http://dx.doi.org/10.14309/crj.0000000000000134
work_keys_str_mv AT shahparth nowyouseeitnowyoudonotacaseofinfliximabinducedvanishingbileductsyndrome
AT larsonbrent nowyouseeitnowyoudonotacaseofinfliximabinducedvanishingbileductsyndrome
AT wishingradmarc nowyouseeitnowyoudonotacaseofinfliximabinducedvanishingbileductsyndrome
AT nissennicholas nowyouseeitnowyoudonotacaseofinfliximabinducedvanishingbileductsyndrome
AT bjornssoneinar nowyouseeitnowyoudonotacaseofinfliximabinducedvanishingbileductsyndrome
AT sundaramvinay nowyouseeitnowyoudonotacaseofinfliximabinducedvanishingbileductsyndrome

Ejemplares similares