Hepatic Sinusoidal Obstruction Syndrome in a Patient With Multiple Myeloma Treated With CyBorD

Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening state generally occurring as a complication of conditioning regimens used for hematopoietic stem cell transplant. Hepatic SOS after a standard dose of chemotherapy in malignancies is rare, and there are only a few cases in pediatric...

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Autores principales: Tariq, Tooba, Dawdy, John, Goyal, Sachin, Mohamad, Bashar, Singh, Manmeet, Mutchnick, Milton, Ehrinpreis, Murray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722380/
https://www.ncbi.nlm.nih.gov/pubmed/31620512
http://dx.doi.org/10.14309/crj.0000000000000103
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author Tariq, Tooba
Dawdy, John
Goyal, Sachin
Mohamad, Bashar
Singh, Manmeet
Mutchnick, Milton
Ehrinpreis, Murray
author_facet Tariq, Tooba
Dawdy, John
Goyal, Sachin
Mohamad, Bashar
Singh, Manmeet
Mutchnick, Milton
Ehrinpreis, Murray
author_sort Tariq, Tooba
collection PubMed
description Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening state generally occurring as a complication of conditioning regimens used for hematopoietic stem cell transplant. Hepatic SOS after a standard dose of chemotherapy in malignancies is rare, and there are only a few cases in pediatric literature. We report a 56-year-old man with multiple myeloma who experienced SOS after being initiated on chemotherapy including cyclophosphamide, dexamethasone, and bortezomib and who experienced a delay in treatment with defibrotide, because it is currently approved by the Food and Drug Administration for only patients who develop SOS after hematopoietic stem cell transplant.
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spelling pubmed-67223802019-10-16 Hepatic Sinusoidal Obstruction Syndrome in a Patient With Multiple Myeloma Treated With CyBorD Tariq, Tooba Dawdy, John Goyal, Sachin Mohamad, Bashar Singh, Manmeet Mutchnick, Milton Ehrinpreis, Murray ACG Case Rep J Case Report Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening state generally occurring as a complication of conditioning regimens used for hematopoietic stem cell transplant. Hepatic SOS after a standard dose of chemotherapy in malignancies is rare, and there are only a few cases in pediatric literature. We report a 56-year-old man with multiple myeloma who experienced SOS after being initiated on chemotherapy including cyclophosphamide, dexamethasone, and bortezomib and who experienced a delay in treatment with defibrotide, because it is currently approved by the Food and Drug Administration for only patients who develop SOS after hematopoietic stem cell transplant. Wolters Kluwer 2019-07-25 /pmc/articles/PMC6722380/ /pubmed/31620512 http://dx.doi.org/10.14309/crj.0000000000000103 Text en © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Tariq, Tooba
Dawdy, John
Goyal, Sachin
Mohamad, Bashar
Singh, Manmeet
Mutchnick, Milton
Ehrinpreis, Murray
Hepatic Sinusoidal Obstruction Syndrome in a Patient With Multiple Myeloma Treated With CyBorD
title Hepatic Sinusoidal Obstruction Syndrome in a Patient With Multiple Myeloma Treated With CyBorD
title_full Hepatic Sinusoidal Obstruction Syndrome in a Patient With Multiple Myeloma Treated With CyBorD
title_fullStr Hepatic Sinusoidal Obstruction Syndrome in a Patient With Multiple Myeloma Treated With CyBorD
title_full_unstemmed Hepatic Sinusoidal Obstruction Syndrome in a Patient With Multiple Myeloma Treated With CyBorD
title_short Hepatic Sinusoidal Obstruction Syndrome in a Patient With Multiple Myeloma Treated With CyBorD
title_sort hepatic sinusoidal obstruction syndrome in a patient with multiple myeloma treated with cybord
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722380/
https://www.ncbi.nlm.nih.gov/pubmed/31620512
http://dx.doi.org/10.14309/crj.0000000000000103
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