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Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population
Previous studies have identified the prostate stem cell antigen (PSCA) gene rs2294008 C > T and rs2976392 G > A polymorphisms to be associated with the risk of gastric cancer, the results of which are inconsistent. The present study aimed to evaluate the association between the two polymorphis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722488/ https://www.ncbi.nlm.nih.gov/pubmed/31416884 http://dx.doi.org/10.1042/BSR20181025 |
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author | Yan, Kangpeng Wu, Kun Lin, Chao Jie, Zhigang |
author_facet | Yan, Kangpeng Wu, Kun Lin, Chao Jie, Zhigang |
author_sort | Yan, Kangpeng |
collection | PubMed |
description | Previous studies have identified the prostate stem cell antigen (PSCA) gene rs2294008 C > T and rs2976392 G > A polymorphisms to be associated with the risk of gastric cancer, the results of which are inconsistent. The present study aimed to evaluate the association between the two polymorphisms and the gastric cancer risk in the Chinese population. A hospital-based case–control study was conducted on 549 cases and 592 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to evaluate the association of the two polymorphisms on the gastric cancer risk. We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20–1.99, P<0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09–1.74, P=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25–2.07, P<0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20–1.92, P<0.001) were associated with an increased gastric cancer. In the combined analysis of the two polymorphisms, subjects with more than one risk genotype have a significantly increased risk of gastric cancer (OR = 1.38, 95% CI = 1.09–1.75, P=0.008) in comparison with those without any risk genotypes. In conclusion, our findings verified that the PSCA gene rs2294008 and rs2976392 polymorphisms were both significantly associated with an increased risk of gastric cancer in the Chinese population. Well-designed functional studies are to be warranted to confirm these findings. |
format | Online Article Text |
id | pubmed-6722488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67224882019-09-09 Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population Yan, Kangpeng Wu, Kun Lin, Chao Jie, Zhigang Biosci Rep Research Articles Previous studies have identified the prostate stem cell antigen (PSCA) gene rs2294008 C > T and rs2976392 G > A polymorphisms to be associated with the risk of gastric cancer, the results of which are inconsistent. The present study aimed to evaluate the association between the two polymorphisms and the gastric cancer risk in the Chinese population. A hospital-based case–control study was conducted on 549 cases and 592 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to evaluate the association of the two polymorphisms on the gastric cancer risk. We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20–1.99, P<0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09–1.74, P=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25–2.07, P<0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20–1.92, P<0.001) were associated with an increased gastric cancer. In the combined analysis of the two polymorphisms, subjects with more than one risk genotype have a significantly increased risk of gastric cancer (OR = 1.38, 95% CI = 1.09–1.75, P=0.008) in comparison with those without any risk genotypes. In conclusion, our findings verified that the PSCA gene rs2294008 and rs2976392 polymorphisms were both significantly associated with an increased risk of gastric cancer in the Chinese population. Well-designed functional studies are to be warranted to confirm these findings. Portland Press Ltd. 2019-09-03 /pmc/articles/PMC6722488/ /pubmed/31416884 http://dx.doi.org/10.1042/BSR20181025 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Yan, Kangpeng Wu, Kun Lin, Chao Jie, Zhigang Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population |
title | Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population |
title_full | Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population |
title_fullStr | Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population |
title_full_unstemmed | Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population |
title_short | Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population |
title_sort | impact of psca gene polymorphisms in modulating gastric cancer risk in the chinese population |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722488/ https://www.ncbi.nlm.nih.gov/pubmed/31416884 http://dx.doi.org/10.1042/BSR20181025 |
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