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Non-CYP2D6 Variants Selected by a GWAS Improve the Prediction of Impaired Tamoxifen Metabolism in Patients with Breast Cancer

A certain minimum plasma concentration of (Z)-endoxifen is presumably required for breast cancer patients to benefit from tamoxifen therapy. In this study, we searched for DNA variants that could aid in the prediction of risk for insufficient (Z)-endoxifen exposure. A metabolic ratio (MR) correspond...

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Detalles Bibliográficos
Autores principales:	Hennig, Ewa E., Piątkowska, Magdalena, Goryca, Krzysztof, Pośpiech, Ewelina, Paziewska, Agnieszka, Karczmarski, Jakub, Kluska, Anna, Brewczyńska, Elżbieta, Ostrowski, Jerzy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722498/ https://www.ncbi.nlm.nih.gov/pubmed/31344832 http://dx.doi.org/10.3390/jcm8081087

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