Design and In Vivo Pharmacokinetic Evaluation of Triamcinolone Acetonide Microcrystals-Loaded PLGA Microsphere for Increased Drug Retention in Knees after Intra-Articular Injection

A novel polymeric microsphere (MS) containing micronized triamcinolone acetonide (TA) in a crystalline state was structured to provide extended drug retention in joints after intra-articular (IA) injection. Microcrystals with a median diameter of 1.7 μm were prepared by ultra-sonication method, and...

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Detalles Bibliográficos
Autores principales: Ho, Myoung Jin, Jeong, Hoe Taek, Im, Sung Hyun, Kim, Hyung Tae, Lee, Jeong Eun, Park, Jun Soo, Cho, Ha Ra, Kim, Dong Yoon, Choi, Young Wook, Lee, Joon Woo, Choi, Yong Seok, Kang, Myung Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722509/
https://www.ncbi.nlm.nih.gov/pubmed/31430878
http://dx.doi.org/10.3390/pharmaceutics11080419

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