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Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome

(1) Background: the composition of high-density lipoproteins (HDL) becomes altered during the postprandial state, probably affecting their functionality vis-à-vis the endothelium. Since acute coronary syndrome (ACS) in women is frequently associated with endothelial dysfunction, it is likely that HD...

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Autores principales: Estrada-Luna, Diego, Carreón-Torres, Elizabeth, Bautista-Pérez, Rocío, Betanzos-Cabrera, Gabriel, Dorantes-Morales, Alan, Luna-Luna, María, Vargas-Barrón, Jesús, Mejía, Ana María, Fragoso, José Manuel, Carvajal-Aguilera, Karla, García-Trejo, José J., Vargas-Alarcón, Gilberto, Pérez-Méndez, Óscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722536/
https://www.ncbi.nlm.nih.gov/pubmed/31349559
http://dx.doi.org/10.3390/nu11081710
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author Estrada-Luna, Diego
Carreón-Torres, Elizabeth
Bautista-Pérez, Rocío
Betanzos-Cabrera, Gabriel
Dorantes-Morales, Alan
Luna-Luna, María
Vargas-Barrón, Jesús
Mejía, Ana María
Fragoso, José Manuel
Carvajal-Aguilera, Karla
García-Trejo, José J.
Vargas-Alarcón, Gilberto
Pérez-Méndez, Óscar
author_facet Estrada-Luna, Diego
Carreón-Torres, Elizabeth
Bautista-Pérez, Rocío
Betanzos-Cabrera, Gabriel
Dorantes-Morales, Alan
Luna-Luna, María
Vargas-Barrón, Jesús
Mejía, Ana María
Fragoso, José Manuel
Carvajal-Aguilera, Karla
García-Trejo, José J.
Vargas-Alarcón, Gilberto
Pérez-Méndez, Óscar
author_sort Estrada-Luna, Diego
collection PubMed
description (1) Background: the composition of high-density lipoproteins (HDL) becomes altered during the postprandial state, probably affecting their functionality vis-à-vis the endothelium. Since acute coronary syndrome (ACS) in women is frequently associated with endothelial dysfunction, it is likely that HDL are unable to improve artery vasodilation in these patients. Therefore, we characterized HDL from women with ACS in fasting and postprandial conditions. We also determined whether microencapsulated pomegranate (MiPo) reverts the HDL abnormalities, since previous studies have suggested that this fruit improves HDL functionality. (2) Methods: Eleven women with a history of ACS were supplemented daily with 20 g of MiPo, for 30 days. Plasma samples were obtained during fasting and at different times, after a lipid load test to determine the lipid profile and paraoxonase–1 (PON1) activity. HDL were isolated by sequential ultracentrifugation to determine their size distribution and to assess their effect on endothelial function, by using an in vitro model of rat aorta rings. (3) Results: MiPo improved the lipid profile and increased PON1 activity, as previously reported, with fresh pomegranate juice. After supplementation with MiPo, the incremental area under the curve of triglycerides decreased to half of the initial values. The HDL distribution shifted from large HDL to intermediate and small-size particles during the postprandial period in the basal conditions, whereas such a shift was no longer observed after MiPo supplementation. Consistently, HDL isolated from postprandial plasma samples hindered the vasodilation of aorta rings, and this endothelial dysfunction was reverted after MiPo consumption. (4) Conclusions: MiPo exhibited the same beneficial effects on the lipid profile and PON1 activity as the previously reported fresh pomegranate. In addition, MiPo supplementation reverted the negative effects of HDL on endothelial function generated during the postprandial period in women with ACS.
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spelling pubmed-67225362019-09-10 Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome Estrada-Luna, Diego Carreón-Torres, Elizabeth Bautista-Pérez, Rocío Betanzos-Cabrera, Gabriel Dorantes-Morales, Alan Luna-Luna, María Vargas-Barrón, Jesús Mejía, Ana María Fragoso, José Manuel Carvajal-Aguilera, Karla García-Trejo, José J. Vargas-Alarcón, Gilberto Pérez-Méndez, Óscar Nutrients Article (1) Background: the composition of high-density lipoproteins (HDL) becomes altered during the postprandial state, probably affecting their functionality vis-à-vis the endothelium. Since acute coronary syndrome (ACS) in women is frequently associated with endothelial dysfunction, it is likely that HDL are unable to improve artery vasodilation in these patients. Therefore, we characterized HDL from women with ACS in fasting and postprandial conditions. We also determined whether microencapsulated pomegranate (MiPo) reverts the HDL abnormalities, since previous studies have suggested that this fruit improves HDL functionality. (2) Methods: Eleven women with a history of ACS were supplemented daily with 20 g of MiPo, for 30 days. Plasma samples were obtained during fasting and at different times, after a lipid load test to determine the lipid profile and paraoxonase–1 (PON1) activity. HDL were isolated by sequential ultracentrifugation to determine their size distribution and to assess their effect on endothelial function, by using an in vitro model of rat aorta rings. (3) Results: MiPo improved the lipid profile and increased PON1 activity, as previously reported, with fresh pomegranate juice. After supplementation with MiPo, the incremental area under the curve of triglycerides decreased to half of the initial values. The HDL distribution shifted from large HDL to intermediate and small-size particles during the postprandial period in the basal conditions, whereas such a shift was no longer observed after MiPo supplementation. Consistently, HDL isolated from postprandial plasma samples hindered the vasodilation of aorta rings, and this endothelial dysfunction was reverted after MiPo consumption. (4) Conclusions: MiPo exhibited the same beneficial effects on the lipid profile and PON1 activity as the previously reported fresh pomegranate. In addition, MiPo supplementation reverted the negative effects of HDL on endothelial function generated during the postprandial period in women with ACS. MDPI 2019-07-25 /pmc/articles/PMC6722536/ /pubmed/31349559 http://dx.doi.org/10.3390/nu11081710 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Estrada-Luna, Diego
Carreón-Torres, Elizabeth
Bautista-Pérez, Rocío
Betanzos-Cabrera, Gabriel
Dorantes-Morales, Alan
Luna-Luna, María
Vargas-Barrón, Jesús
Mejía, Ana María
Fragoso, José Manuel
Carvajal-Aguilera, Karla
García-Trejo, José J.
Vargas-Alarcón, Gilberto
Pérez-Méndez, Óscar
Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome
title Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome
title_full Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome
title_fullStr Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome
title_full_unstemmed Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome
title_short Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome
title_sort microencapsulated pomegranate reverts high-density lipoprotein (hdl)-induced endothelial dysfunction and reduces postprandial triglyceridemia in women with acute coronary syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722536/
https://www.ncbi.nlm.nih.gov/pubmed/31349559
http://dx.doi.org/10.3390/nu11081710
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