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Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome

Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fever orthonairovirus can vary from a mild, nonspeci...

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Autores principales: Korva, Miša, Resman Rus, Katarina, Pavletič, Miša, Saksida, Ana, Knap, Nataša, Jelovšek, Mateja, Strašek Smrdel, Katja, Jakupi, Xhevat, Humolli, Isme, Dedushaj, Jusuf, Petrovec, Miroslav, Avšič-Županc, Tatjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722556/
https://www.ncbi.nlm.nih.gov/pubmed/31357521
http://dx.doi.org/10.3390/v11080686
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author Korva, Miša
Resman Rus, Katarina
Pavletič, Miša
Saksida, Ana
Knap, Nataša
Jelovšek, Mateja
Strašek Smrdel, Katja
Jakupi, Xhevat
Humolli, Isme
Dedushaj, Jusuf
Petrovec, Miroslav
Avšič-Županc, Tatjana
author_facet Korva, Miša
Resman Rus, Katarina
Pavletič, Miša
Saksida, Ana
Knap, Nataša
Jelovšek, Mateja
Strašek Smrdel, Katja
Jakupi, Xhevat
Humolli, Isme
Dedushaj, Jusuf
Petrovec, Miroslav
Avšič-Županc, Tatjana
author_sort Korva, Miša
collection PubMed
description Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fever orthonairovirus can vary from a mild, nonspecific febrile illness, to a severe disease with a fatal outcome. The pathogenesis of both diseases is poorly understood, but it has been suggested that a host’s immune mechanism might influence the pathogenesis of the diseases and survival. The aim of our study is to characterize cytokine response in patients with VHF in association with the disease progression and viral load. Forty soluble mediators of the immune response, coagulation, and endothelial dysfunction were measured in acute serum samples in 100 HFRS patients and 70 CCHF patients. HFRS and CCHF patients had significantly increased levels of IL-6, IL-12p70, IP-10, INF-γ, TNF-α, GM-CSF, MCP-3, and MIP-1b in comparison to the control group. Interestingly, HFRS patients had higher concentrations of serum MIP-1α, MIP-1β, which promote activation of macrophages and NK cells. HFRS patients had increased concentrations of IFN-γ and TNF-α, while CCHF patients had significantly higher concentrations of IFN-α and IL-8. In both, CCHF and HFRS patients’ viral load significantly correlated with IP-10. Patients with fatal outcome had significantly elevated concentrations of IL-6, IFN-α2 and MIP-1α, while GRO-α, chemokine related to activation of neutrophils and basophils, was downregulated. Our study provided a comprehensive characterization of biomarkers released in the acute stages of CCHF and HFRS.
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spelling pubmed-67225562019-09-10 Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome Korva, Miša Resman Rus, Katarina Pavletič, Miša Saksida, Ana Knap, Nataša Jelovšek, Mateja Strašek Smrdel, Katja Jakupi, Xhevat Humolli, Isme Dedushaj, Jusuf Petrovec, Miroslav Avšič-Županc, Tatjana Viruses Article Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fever orthonairovirus can vary from a mild, nonspecific febrile illness, to a severe disease with a fatal outcome. The pathogenesis of both diseases is poorly understood, but it has been suggested that a host’s immune mechanism might influence the pathogenesis of the diseases and survival. The aim of our study is to characterize cytokine response in patients with VHF in association with the disease progression and viral load. Forty soluble mediators of the immune response, coagulation, and endothelial dysfunction were measured in acute serum samples in 100 HFRS patients and 70 CCHF patients. HFRS and CCHF patients had significantly increased levels of IL-6, IL-12p70, IP-10, INF-γ, TNF-α, GM-CSF, MCP-3, and MIP-1b in comparison to the control group. Interestingly, HFRS patients had higher concentrations of serum MIP-1α, MIP-1β, which promote activation of macrophages and NK cells. HFRS patients had increased concentrations of IFN-γ and TNF-α, while CCHF patients had significantly higher concentrations of IFN-α and IL-8. In both, CCHF and HFRS patients’ viral load significantly correlated with IP-10. Patients with fatal outcome had significantly elevated concentrations of IL-6, IFN-α2 and MIP-1α, while GRO-α, chemokine related to activation of neutrophils and basophils, was downregulated. Our study provided a comprehensive characterization of biomarkers released in the acute stages of CCHF and HFRS. MDPI 2019-07-26 /pmc/articles/PMC6722556/ /pubmed/31357521 http://dx.doi.org/10.3390/v11080686 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Korva, Miša
Resman Rus, Katarina
Pavletič, Miša
Saksida, Ana
Knap, Nataša
Jelovšek, Mateja
Strašek Smrdel, Katja
Jakupi, Xhevat
Humolli, Isme
Dedushaj, Jusuf
Petrovec, Miroslav
Avšič-Županc, Tatjana
Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome
title Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome
title_full Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome
title_fullStr Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome
title_full_unstemmed Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome
title_short Characterization of Biomarker Levels in Crimean–Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome
title_sort characterization of biomarker levels in crimean–congo hemorrhagic fever and hantavirus fever with renal syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722556/
https://www.ncbi.nlm.nih.gov/pubmed/31357521
http://dx.doi.org/10.3390/v11080686
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