Cargando…

A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology

Acute myeloid leukemia (AML) is one of the most frequent, complex, and heterogeneous hematological malignancies. AML prognosis largely depends on acquired cytogenetic, epigenetic, and molecular abnormalities. Despite the improvement in understanding the biology of AML, survival rates remain quite lo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Skayneh, Hala, Jishi, Batoul, Hleihel, Rita, Hamieh, Maguy, Darwiche, Nadine, Bazarbachi, Ali, El Sabban, Marwan, El Hajj, Hiba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722578/ https://www.ncbi.nlm.nih.gov/pubmed/31412687 http://dx.doi.org/10.3390/genes10080614

Ejemplares similares

EAPB0503, an Imidazoquinoxaline Derivative Modulates SENP3/ARF Mediated SUMOylation, and Induces NPM1c Degradation in NPM1 Mutant AML
por: Skayneh, Hala, et al.
Publicado: (2022)

Mouse Models That Enhanced Our Understanding of Adult T Cell Leukemia
por: Moodad, Sara, et al.
Publicado: (2018)

In vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ
por: Akkouche, Abdou, et al.
Publicado: (2021)

A Pin1/PML/P53 axis activated by retinoic acid in NPM-1c acute myeloid leukemia
por: Hleihel, Rita, et al.
Publicado: (2021)

Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival
por: Hleihel, Rita, et al.
Publicado: (2023)

Lenalidomide in Combination with Arsenic Trioxide: an Effective Therapy for Primary Effusion Lymphoma
por: Moodad, Sara, et al.
Publicado: (2020)

Loss of interleukin-10 activates innate immunity to eradicate adult T-cell leukemia-initiating cells
por: El Hajj, Hiba, et al.
Publicado: (2021)

P18 (SRS35/TgSAG4) Plays a Role in the Invasion and Virulence of Toxoplasma gondii
por: Hamie, Maguy, et al.
Publicado: (2021)

Toxoplasmosis: Current and Emerging Parasite Druggable Targets
por: Hajj, Rana El, et al.
Publicado: (2021)

Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia
por: El Hajj, Hiba, et al.
Publicado: (2022)

Deciphering the molecular basis of arsenic/interferon-alpha induced eradication of leukemia initiating cells in adult T cell leukemia
por: El Hajj, Hiba, et al.
Publicado: (2015)

Validation of a Drosophila model of wild-type and T315I mutated BCR-ABL1 in chronic myeloid leukemia: an effective platform for treatment screening
por: Outa, Amani Al, et al.
Publicado: (2020)

Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia
por: El Hajj, Hiba, et al.
Publicado: (2010)

Imiquimod Targets Toxoplasmosis Through Modulating Host Toll-Like Receptor-MyD88 Signaling
por: Hamie, Maguy, et al.
Publicado: (2021)

The HTLV-1 oncoprotein Tax is modified by the ubiquitin related modifier 1 (Urm1)
por: Hleihel, Rita, et al.
Publicado: (2018)

Comprehensive Overview of Toxoplasma gondii-Induced and Associated Diseases
por: Daher, Darine, et al.
Publicado: (2021)

Novel Treatments of Adult T Cell Leukemia Lymphoma
por: El Hajj, Hiba, et al.
Publicado: (2020)

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome
por: Kfoury, Youmna, et al.
Publicado: (2011)

Controversies in Targeted Therapy of Adult T Cell Leukemia/Lymphoma: ON Target or OFF Target Effects?
por: Nasr, Rihab, et al.
Publicado: (2011)

Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines
por: El-Hajjar, Layal, et al.
Publicado: (2023)

Hetero-cellular interaction between cancer cells and stem cells in cancer metastasis
por: El Saghir, Jamal, et al.
Publicado: (2011)

Updates on the Epidemiology of the Human T-Cell Leukemia Virus Type 1 Infection in the Countries of the Eastern Mediterranean Regional Office of the World Health Organization with Special Emphasis on the Situation in Iran
por: Hedayati-Moghaddam, Mohammad Reza, et al.
Publicado: (2022)

Combination of Arsenic and Interferon-α Inhibits Expression of KSHV Latent Transcripts and Synergistically Improves Survival of Mice with Primary Effusion Lymphomas
por: El Hajj, Hiba, et al.
Publicado: (2013)

Pathophysiology of Coagulation and Emerging Roles for Extracellular Vesicles in Coagulation Cascades and Disorders
por: Al-Koussa, Houssam, et al.
Publicado: (2022)

Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells
por: Kouzi, Farah, et al.
Publicado: (2019)

Antioxidant activity of pomegranate juice reduces emphysematous changes and injury secondary to cigarette smoke in an animal model and human alveolar cells
por: Husari, Ahmad, et al.
Publicado: (2016)

Pharmacologic Strategies for Post-Transplant Maintenance in Acute Myeloid Leukemia: It Is Time to Consider!
por: Abou Dalle, Iman, et al.
Publicado: (2022)

Post-Transplant Maintenance Therapy for Patients with Acute Myeloid Leukemia: Current Approaches and the Need for More Trials
por: Assi, Rita, et al.
Publicado: (2021)

Animal models on HTLV-1 and related viruses: what did we learn?
por: Hajj, Hiba El, et al.
Publicado: (2012)

Correction: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells
por: Kouzi, Farah, et al.
Publicado: (2019)

Antioxidant activity of pomegranate juice reduces acute lung injury secondary to hyperoxia in an animal model
por: Husari, Ahmad, et al.
Publicado: (2014)

Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells
por: Hamad, Ahmad, et al.
Publicado: (2013)

Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation
por: Shirinian, Margret, et al.
Publicado: (2013)

ATL-derived exosomes modulate mesenchymal stem cells: potential role in leukemia progression
por: El-Saghir, Jamal, et al.
Publicado: (2016)

Use of the job demands-resource model to understand community pharmacists’ burnout during the COVID-19 pandemic
por: Abdelsadig Mohammed, Hiba, et al.
Publicado: (2022)

Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model
por: Husari, Ahmad, et al.
Publicado: (2017)

New drugs before, during, and after hematopoietic stem cell transplantation for patients with acute myeloid leukemia
por: Mohty, Razan, et al.
Publicado: (2023)

HAS 1: A natural product from soil-isolated Streptomyces species with potent activity against cutaneous leishmaniasis caused by Leishmania tropica
por: Awada, Bassel, et al.
Publicado: (2022)

Reciprocal communication between mesenchymal stem cells and leukemic cells: role of junctional complexes and exosomes in adult T-cell leukemia progression
por: El-Saghir, Jamal, et al.
Publicado: (2015)

Acellular Bone Marrow Extracts Significantly Enhance Engraftment Levels of Human Hematopoietic Stem Cells in Mouse Xeno-Transplantation Models
por: Zibara, Kazem, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_mrpdat78q3dsed4ctlj5bef760