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Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome
Lifestyle is a well-known environmental factor that plays a major role in facilitating the development of metabolic syndrome or eventually exacerbating its consequences. Various lifestyle factors, especially changes in dietary habits, extreme temperatures, unusual light–dark cycles, substance abuse,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722643/ https://www.ncbi.nlm.nih.gov/pubmed/31434293 http://dx.doi.org/10.3390/nu11081956 |
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author | Di Marzo, Vincenzo Silvestri, Cristoforo |
author_facet | Di Marzo, Vincenzo Silvestri, Cristoforo |
author_sort | Di Marzo, Vincenzo |
collection | PubMed |
description | Lifestyle is a well-known environmental factor that plays a major role in facilitating the development of metabolic syndrome or eventually exacerbating its consequences. Various lifestyle factors, especially changes in dietary habits, extreme temperatures, unusual light–dark cycles, substance abuse, and other stressful factors, are also established modifiers of the endocannabinoid system and its extended version, the endocannabinoidome. The endocannabinoidome is a complex lipid signaling system composed of a plethora (>100) of fatty acid-derived mediators and their receptors and anabolic and catabolic enzymes (>50 proteins) which are deeply involved in the control of energy metabolism and its pathological deviations. A strong link between the endocannabinoidome and another major player in metabolism and dysmetabolism, the gut microbiome, is also emerging. Here, we review several examples of how lifestyle modifications (westernized diets, lack or presence of certain nutritional factors, physical exercise, and the use of cannabis) can modulate the propensity to develop metabolic syndrome by modifying the crosstalk between the endocannabinoidome and the gut microbiome and, hence, how lifestyle interventions can provide new therapies against cardiometabolic risk by ensuring correct functioning of both these systems. |
format | Online Article Text |
id | pubmed-6722643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67226432019-09-10 Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome Di Marzo, Vincenzo Silvestri, Cristoforo Nutrients Review Lifestyle is a well-known environmental factor that plays a major role in facilitating the development of metabolic syndrome or eventually exacerbating its consequences. Various lifestyle factors, especially changes in dietary habits, extreme temperatures, unusual light–dark cycles, substance abuse, and other stressful factors, are also established modifiers of the endocannabinoid system and its extended version, the endocannabinoidome. The endocannabinoidome is a complex lipid signaling system composed of a plethora (>100) of fatty acid-derived mediators and their receptors and anabolic and catabolic enzymes (>50 proteins) which are deeply involved in the control of energy metabolism and its pathological deviations. A strong link between the endocannabinoidome and another major player in metabolism and dysmetabolism, the gut microbiome, is also emerging. Here, we review several examples of how lifestyle modifications (westernized diets, lack or presence of certain nutritional factors, physical exercise, and the use of cannabis) can modulate the propensity to develop metabolic syndrome by modifying the crosstalk between the endocannabinoidome and the gut microbiome and, hence, how lifestyle interventions can provide new therapies against cardiometabolic risk by ensuring correct functioning of both these systems. MDPI 2019-08-20 /pmc/articles/PMC6722643/ /pubmed/31434293 http://dx.doi.org/10.3390/nu11081956 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Di Marzo, Vincenzo Silvestri, Cristoforo Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome |
title | Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome |
title_full | Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome |
title_fullStr | Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome |
title_full_unstemmed | Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome |
title_short | Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome |
title_sort | lifestyle and metabolic syndrome: contribution of the endocannabinoidome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722643/ https://www.ncbi.nlm.nih.gov/pubmed/31434293 http://dx.doi.org/10.3390/nu11081956 |
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