Transcriptomic Analysis of the Influence of Methanol Assimilation on the Gene Expression in the Recombinant Pichia pastoris Producing Hirudin Variant 3

Hirudin and its variants, as strong inhibitors against thrombin, are present in the saliva of leeches and are recognized as potent anticoagulants. However, their yield is far from the clinical requirement up to now. In this study, the production of hirudin variant 3 (HV3) was successfully realized b...

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Detalles Bibliográficos
Autores principales: Li, Tao, Ma, Jieying, Xu, Zehua, Wang, Shuang, Wang, Nan, Shao, Shulin, Yang, Wei, Huang, Lin, Liu, Yihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722669/
https://www.ncbi.nlm.nih.gov/pubmed/31409011
http://dx.doi.org/10.3390/genes10080606

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