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Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults

Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index...

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Autores principales: Atkinson, Fiona S., Villar, Agusti, Mulà, Anna, Zangara, Andrea, Risco, Ester, Smidt, Carsten R., Hontecillas, Raquel, Leber, Andrew, Bassaganya-Riera, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722713/
https://www.ncbi.nlm.nih.gov/pubmed/31370154
http://dx.doi.org/10.3390/nu11081757
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author Atkinson, Fiona S.
Villar, Agusti
Mulà, Anna
Zangara, Andrea
Risco, Ester
Smidt, Carsten R.
Hontecillas, Raquel
Leber, Andrew
Bassaganya-Riera, Josep
author_facet Atkinson, Fiona S.
Villar, Agusti
Mulà, Anna
Zangara, Andrea
Risco, Ester
Smidt, Carsten R.
Hontecillas, Raquel
Leber, Andrew
Bassaganya-Riera, Josep
author_sort Atkinson, Fiona S.
collection PubMed
description Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index (II) to a standard glucose drink. In a randomized, double-blind crossover study, 10 healthy adults consumed 4 test beverages containing FFE with postprandial glucose and insulin assessed at regular intervals over 2 h to determine GI and II responses. Test beverages containing 200 mg FFE-50× and 1200 mg FFE-10× significantly reduced GI values by −25% (P = 0.001) and −24% (P = 0.002), respectively. Two lower doses of FFE also reduced GI values compared with the reference drink (by approximately −14%), but the differences did not reach statistical significance. Addition of FFE to the glucose solution significantly reduced II values at all dosages and displayed a clear dose-response reduction: FFE-50× at 100 mg and 200 mg (−14% (P < 0.05) and −24% (P = 0.01), respectively) and FFE-10× at 600 mg and 1200 mg (−16% (P < 0.05) and −24% (P = 0.01), respectively). FFE supplementation is a promising nutritional intervention for the management of acute postprandial glucose and insulin homeostasis, and it is a possible adjunctive treatment for glycemic management of chronic metabolic disorders such as prediabetes and type 2 diabetes mellitus.
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spelling pubmed-67227132019-09-10 Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults Atkinson, Fiona S. Villar, Agusti Mulà, Anna Zangara, Andrea Risco, Ester Smidt, Carsten R. Hontecillas, Raquel Leber, Andrew Bassaganya-Riera, Josep Nutrients Article Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index (II) to a standard glucose drink. In a randomized, double-blind crossover study, 10 healthy adults consumed 4 test beverages containing FFE with postprandial glucose and insulin assessed at regular intervals over 2 h to determine GI and II responses. Test beverages containing 200 mg FFE-50× and 1200 mg FFE-10× significantly reduced GI values by −25% (P = 0.001) and −24% (P = 0.002), respectively. Two lower doses of FFE also reduced GI values compared with the reference drink (by approximately −14%), but the differences did not reach statistical significance. Addition of FFE to the glucose solution significantly reduced II values at all dosages and displayed a clear dose-response reduction: FFE-50× at 100 mg and 200 mg (−14% (P < 0.05) and −24% (P = 0.01), respectively) and FFE-10× at 600 mg and 1200 mg (−16% (P < 0.05) and −24% (P = 0.01), respectively). FFE supplementation is a promising nutritional intervention for the management of acute postprandial glucose and insulin homeostasis, and it is a possible adjunctive treatment for glycemic management of chronic metabolic disorders such as prediabetes and type 2 diabetes mellitus. MDPI 2019-07-31 /pmc/articles/PMC6722713/ /pubmed/31370154 http://dx.doi.org/10.3390/nu11081757 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Atkinson, Fiona S.
Villar, Agusti
Mulà, Anna
Zangara, Andrea
Risco, Ester
Smidt, Carsten R.
Hontecillas, Raquel
Leber, Andrew
Bassaganya-Riera, Josep
Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
title Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
title_full Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
title_fullStr Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
title_full_unstemmed Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
title_short Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
title_sort abscisic acid standardized fig (ficus carica) extracts ameliorate postprandial glycemic and insulinemic responses in healthy adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722713/
https://www.ncbi.nlm.nih.gov/pubmed/31370154
http://dx.doi.org/10.3390/nu11081757
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