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Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722713/ https://www.ncbi.nlm.nih.gov/pubmed/31370154 http://dx.doi.org/10.3390/nu11081757 |
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author | Atkinson, Fiona S. Villar, Agusti Mulà, Anna Zangara, Andrea Risco, Ester Smidt, Carsten R. Hontecillas, Raquel Leber, Andrew Bassaganya-Riera, Josep |
author_facet | Atkinson, Fiona S. Villar, Agusti Mulà, Anna Zangara, Andrea Risco, Ester Smidt, Carsten R. Hontecillas, Raquel Leber, Andrew Bassaganya-Riera, Josep |
author_sort | Atkinson, Fiona S. |
collection | PubMed |
description | Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index (II) to a standard glucose drink. In a randomized, double-blind crossover study, 10 healthy adults consumed 4 test beverages containing FFE with postprandial glucose and insulin assessed at regular intervals over 2 h to determine GI and II responses. Test beverages containing 200 mg FFE-50× and 1200 mg FFE-10× significantly reduced GI values by −25% (P = 0.001) and −24% (P = 0.002), respectively. Two lower doses of FFE also reduced GI values compared with the reference drink (by approximately −14%), but the differences did not reach statistical significance. Addition of FFE to the glucose solution significantly reduced II values at all dosages and displayed a clear dose-response reduction: FFE-50× at 100 mg and 200 mg (−14% (P < 0.05) and −24% (P = 0.01), respectively) and FFE-10× at 600 mg and 1200 mg (−16% (P < 0.05) and −24% (P = 0.01), respectively). FFE supplementation is a promising nutritional intervention for the management of acute postprandial glucose and insulin homeostasis, and it is a possible adjunctive treatment for glycemic management of chronic metabolic disorders such as prediabetes and type 2 diabetes mellitus. |
format | Online Article Text |
id | pubmed-6722713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67227132019-09-10 Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults Atkinson, Fiona S. Villar, Agusti Mulà, Anna Zangara, Andrea Risco, Ester Smidt, Carsten R. Hontecillas, Raquel Leber, Andrew Bassaganya-Riera, Josep Nutrients Article Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index (II) to a standard glucose drink. In a randomized, double-blind crossover study, 10 healthy adults consumed 4 test beverages containing FFE with postprandial glucose and insulin assessed at regular intervals over 2 h to determine GI and II responses. Test beverages containing 200 mg FFE-50× and 1200 mg FFE-10× significantly reduced GI values by −25% (P = 0.001) and −24% (P = 0.002), respectively. Two lower doses of FFE also reduced GI values compared with the reference drink (by approximately −14%), but the differences did not reach statistical significance. Addition of FFE to the glucose solution significantly reduced II values at all dosages and displayed a clear dose-response reduction: FFE-50× at 100 mg and 200 mg (−14% (P < 0.05) and −24% (P = 0.01), respectively) and FFE-10× at 600 mg and 1200 mg (−16% (P < 0.05) and −24% (P = 0.01), respectively). FFE supplementation is a promising nutritional intervention for the management of acute postprandial glucose and insulin homeostasis, and it is a possible adjunctive treatment for glycemic management of chronic metabolic disorders such as prediabetes and type 2 diabetes mellitus. MDPI 2019-07-31 /pmc/articles/PMC6722713/ /pubmed/31370154 http://dx.doi.org/10.3390/nu11081757 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Atkinson, Fiona S. Villar, Agusti Mulà, Anna Zangara, Andrea Risco, Ester Smidt, Carsten R. Hontecillas, Raquel Leber, Andrew Bassaganya-Riera, Josep Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults |
title | Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults |
title_full | Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults |
title_fullStr | Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults |
title_full_unstemmed | Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults |
title_short | Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults |
title_sort | abscisic acid standardized fig (ficus carica) extracts ameliorate postprandial glycemic and insulinemic responses in healthy adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722713/ https://www.ncbi.nlm.nih.gov/pubmed/31370154 http://dx.doi.org/10.3390/nu11081757 |
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