Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112

Three new lactones penicilactones A−C (1−3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo(2)(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (C...

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Detalles Bibliográficos
Autores principales: Bai, Meng, Huang, Guo-Lei, Mei, Rong-Qing, Wang, Bin, Luo, You-Ping, Nong, Xu-Hua, Chen, Guang-Ying, Zheng, Cai-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722761/
https://www.ncbi.nlm.nih.gov/pubmed/31344841
http://dx.doi.org/10.3390/md17080433
Descripción
Sumario:Three new lactones penicilactones A−C (1−3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo(2)(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC(50) value of 78.5 (±0.58) μg/mL.

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