Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112

Three new lactones penicilactones A−C (1−3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo(2)(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (C...

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Autores principales: Bai, Meng, Huang, Guo-Lei, Mei, Rong-Qing, Wang, Bin, Luo, You-Ping, Nong, Xu-Hua, Chen, Guang-Ying, Zheng, Cai-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722761/
https://www.ncbi.nlm.nih.gov/pubmed/31344841
http://dx.doi.org/10.3390/md17080433
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author Bai, Meng
Huang, Guo-Lei
Mei, Rong-Qing
Wang, Bin
Luo, You-Ping
Nong, Xu-Hua
Chen, Guang-Ying
Zheng, Cai-Juan
author_facet Bai, Meng
Huang, Guo-Lei
Mei, Rong-Qing
Wang, Bin
Luo, You-Ping
Nong, Xu-Hua
Chen, Guang-Ying
Zheng, Cai-Juan
author_sort Bai, Meng
collection PubMed
description Three new lactones penicilactones A−C (1−3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo(2)(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC(50) value of 78.5 (±0.58) μg/mL.
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spelling pubmed-67227612019-09-10 Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112 Bai, Meng Huang, Guo-Lei Mei, Rong-Qing Wang, Bin Luo, You-Ping Nong, Xu-Hua Chen, Guang-Ying Zheng, Cai-Juan Mar Drugs Article Three new lactones penicilactones A−C (1−3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo(2)(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC(50) value of 78.5 (±0.58) μg/mL. MDPI 2019-07-24 /pmc/articles/PMC6722761/ /pubmed/31344841 http://dx.doi.org/10.3390/md17080433 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bai, Meng
Huang, Guo-Lei
Mei, Rong-Qing
Wang, Bin
Luo, You-Ping
Nong, Xu-Hua
Chen, Guang-Ying
Zheng, Cai-Juan
Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112
title Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112
title_full Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112
title_fullStr Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112
title_full_unstemmed Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112
title_short Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112
title_sort bioactive lactones from the mangrove-derived fungus penicillium sp. tgm112
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722761/
https://www.ncbi.nlm.nih.gov/pubmed/31344841
http://dx.doi.org/10.3390/md17080433
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